Pediatric anesthesia and neurotoxicity: Can findings be translated from animals to humans?

Nicola Disma*, Tom G. Hansen

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Many studies have demonstrated a neurodegenerative effect of anesthetic drugs in cubs and young animals, raising the concern that similar effects can happen in children, and that the administration of anesthesia in young children undergoing surgical or diagnostic procedures may cause long- Term neurocognitive impairment. Thus, several epidemiological studies have been performed with the aim to find a possible association between early anesthesia exposure and poor long- Term outcome, like learning disabilities or worse school grading and two prospective trials are currently running, the GAS and the PANDA study. Interim results from the GAS study, which compared infants undergoing general and regional anesthesia for hernia repair, have demonstrated that a single exposure of about one hour of anesthesia does not affect the neurological outcome at 2 years of age. Nowadays, most of the knowledge in the field of anesthesia and its potential long- Term effects comes from studies performed in animals, but findings are difficult to extrapolate and they do not predict results from similar studies performed in humans. Nonetheless, studies in animals are necessary to better understand the effects of anesthetics and the mechanistic of potential anesthesia-related neurotoxicity. Studies in humans must run in parallel in order to determine whether similar effects may occur in young patients. (Cite this article as: Disma N, Hansen TG. Pediatric anesthesia and neurotoxicity: can findings be translated from animals to humans? Minerva Anestesiol 2016;82:791-6).

Original languageEnglish
JournalMinerva Anestesiologica
Volume82
Issue number7
Pages (from-to)791-796
ISSN0375-9393
Publication statusPublished - 2016

Fingerprint

Pediatrics
Herniorrhaphy
Epidemiologic Studies

Keywords

  • Anesthesia
  • Neurotoxicity syndromes
  • Pediatrics
  • Time

Cite this

@article{febca8f1d3f24e27942b9e3f6514df49,
title = "Pediatric anesthesia and neurotoxicity: Can findings be translated from animals to humans?",
abstract = "Many studies have demonstrated a neurodegenerative effect of anesthetic drugs in cubs and young animals, raising the concern that similar effects can happen in children, and that the administration of anesthesia in young children undergoing surgical or diagnostic procedures may cause long- Term neurocognitive impairment. Thus, several epidemiological studies have been performed with the aim to find a possible association between early anesthesia exposure and poor long- Term outcome, like learning disabilities or worse school grading and two prospective trials are currently running, the GAS and the PANDA study. Interim results from the GAS study, which compared infants undergoing general and regional anesthesia for hernia repair, have demonstrated that a single exposure of about one hour of anesthesia does not affect the neurological outcome at 2 years of age. Nowadays, most of the knowledge in the field of anesthesia and its potential long- Term effects comes from studies performed in animals, but findings are difficult to extrapolate and they do not predict results from similar studies performed in humans. Nonetheless, studies in animals are necessary to better understand the effects of anesthetics and the mechanistic of potential anesthesia-related neurotoxicity. Studies in humans must run in parallel in order to determine whether similar effects may occur in young patients. (Cite this article as: Disma N, Hansen TG. Pediatric anesthesia and neurotoxicity: can findings be translated from animals to humans? Minerva Anestesiol 2016;82:791-6).",
keywords = "Anesthesia, Neurotoxicity syndromes, Pediatrics, Time",
author = "Nicola Disma and Hansen, {Tom G.}",
year = "2016",
language = "English",
volume = "82",
pages = "791--796",
journal = "Minerva Anestesiologica",
issn = "0375-9393",
publisher = "EdizioniMinerva Medica",
number = "7",

}

Pediatric anesthesia and neurotoxicity : Can findings be translated from animals to humans? / Disma, Nicola; Hansen, Tom G.

In: Minerva Anestesiologica, Vol. 82, No. 7, 2016, p. 791-796.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Pediatric anesthesia and neurotoxicity

T2 - Can findings be translated from animals to humans?

AU - Disma, Nicola

AU - Hansen, Tom G.

PY - 2016

Y1 - 2016

N2 - Many studies have demonstrated a neurodegenerative effect of anesthetic drugs in cubs and young animals, raising the concern that similar effects can happen in children, and that the administration of anesthesia in young children undergoing surgical or diagnostic procedures may cause long- Term neurocognitive impairment. Thus, several epidemiological studies have been performed with the aim to find a possible association between early anesthesia exposure and poor long- Term outcome, like learning disabilities or worse school grading and two prospective trials are currently running, the GAS and the PANDA study. Interim results from the GAS study, which compared infants undergoing general and regional anesthesia for hernia repair, have demonstrated that a single exposure of about one hour of anesthesia does not affect the neurological outcome at 2 years of age. Nowadays, most of the knowledge in the field of anesthesia and its potential long- Term effects comes from studies performed in animals, but findings are difficult to extrapolate and they do not predict results from similar studies performed in humans. Nonetheless, studies in animals are necessary to better understand the effects of anesthetics and the mechanistic of potential anesthesia-related neurotoxicity. Studies in humans must run in parallel in order to determine whether similar effects may occur in young patients. (Cite this article as: Disma N, Hansen TG. Pediatric anesthesia and neurotoxicity: can findings be translated from animals to humans? Minerva Anestesiol 2016;82:791-6).

AB - Many studies have demonstrated a neurodegenerative effect of anesthetic drugs in cubs and young animals, raising the concern that similar effects can happen in children, and that the administration of anesthesia in young children undergoing surgical or diagnostic procedures may cause long- Term neurocognitive impairment. Thus, several epidemiological studies have been performed with the aim to find a possible association between early anesthesia exposure and poor long- Term outcome, like learning disabilities or worse school grading and two prospective trials are currently running, the GAS and the PANDA study. Interim results from the GAS study, which compared infants undergoing general and regional anesthesia for hernia repair, have demonstrated that a single exposure of about one hour of anesthesia does not affect the neurological outcome at 2 years of age. Nowadays, most of the knowledge in the field of anesthesia and its potential long- Term effects comes from studies performed in animals, but findings are difficult to extrapolate and they do not predict results from similar studies performed in humans. Nonetheless, studies in animals are necessary to better understand the effects of anesthetics and the mechanistic of potential anesthesia-related neurotoxicity. Studies in humans must run in parallel in order to determine whether similar effects may occur in young patients. (Cite this article as: Disma N, Hansen TG. Pediatric anesthesia and neurotoxicity: can findings be translated from animals to humans? Minerva Anestesiol 2016;82:791-6).

KW - Anesthesia

KW - Neurotoxicity syndromes

KW - Pediatrics

KW - Time

M3 - Review

AN - SCOPUS:84979955510

VL - 82

SP - 791

EP - 796

JO - Minerva Anestesiologica

JF - Minerva Anestesiologica

SN - 0375-9393

IS - 7

ER -