Patient self-testing of white blood cell count and differentiation: A study of feasibility and measurement performance in a population of Danish cancer patients

Thea Otto Mattsson*, Christina Louise Lindhardt, Jonas Schöley, Lennart Friis-Hansen, Jørn Herrstedt (Member of author group)

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: Patients in anticancer treatment with a known side effect of neutropenia are monitored closely with laboratory measurements of white blood cell count (WBC) and differentiation. This study sought to evaluate measurement properties and feasibility of patients' self-testing using a point-of-care testing (POCT) device. Methods: A prospective feasibility and measurement study comparing the standard measurement of cancer patients' WBC and neutrophil count with POCT measurements. The study included 60 outpatients and 22 inpatients from a department of oncology at a university hospital. Results: Patients successfully conducted 106 measurements using the POCT device. 46% of the patients were >70 years. Weighted Deming regression analysis showed minimal yet significant proportional bias between methods, with POCT increasingly underestimating both total WBC and neutrophils compared with the standard method the higher the count. Over 90% of patients reported they were willing and considered themselves able to use the POCT device at home. Conclusions: The instrument can be used for self-testing of post-anticancer leukopenia and has sufficient measurement precision for patient risk stratification. Patients are able and willing to conduct measurements including when in a situation of acute illness. Further studies are needed to confirm safety and value within patients’ own home.

Original languageEnglish
Article numbere13189
JournalEuropean Journal of Cancer Care
Volume29
Issue number1
Number of pages11
ISSN0961-5423
DOIs
Publication statusPublished - 1. Jan 2020

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Feasibility Studies
Cell Differentiation
Population
Neoplasms
Equipment and Supplies
Neutrophils
Leukopenia
Neutropenia
Inpatients
Outpatients
Regression Analysis
Point-of-Care Testing
Safety

Keywords

  • aged
  • antineoplastic agents
  • febrile neutropenia
  • medical oncology
  • patient comfort
  • patient education
  • point-of-care testing

Cite this

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title = "Patient self-testing of white blood cell count and differentiation: A study of feasibility and measurement performance in a population of Danish cancer patients",
abstract = "Objective: Patients in anticancer treatment with a known side effect of neutropenia are monitored closely with laboratory measurements of white blood cell count (WBC) and differentiation. This study sought to evaluate measurement properties and feasibility of patients' self-testing using a point-of-care testing (POCT) device. Methods: A prospective feasibility and measurement study comparing the standard measurement of cancer patients' WBC and neutrophil count with POCT measurements. The study included 60 outpatients and 22 inpatients from a department of oncology at a university hospital. Results: Patients successfully conducted 106 measurements using the POCT device. 46{\%} of the patients were >70 years. Weighted Deming regression analysis showed minimal yet significant proportional bias between methods, with POCT increasingly underestimating both total WBC and neutrophils compared with the standard method the higher the count. Over 90{\%} of patients reported they were willing and considered themselves able to use the POCT device at home. Conclusions: The instrument can be used for self-testing of post-anticancer leukopenia and has sufficient measurement precision for patient risk stratification. Patients are able and willing to conduct measurements including when in a situation of acute illness. Further studies are needed to confirm safety and value within patients’ own home.",
keywords = "aged, antineoplastic agents, febrile neutropenia, medical oncology, patient comfort, patient education, point-of-care testing",
author = "{Otto Mattsson}, Thea and Lindhardt, {Christina Louise} and Jonas Sch{\"o}ley and Lennart Friis-Hansen and J{\o}rn Herrstedt",
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doi = "10.1111/ecc.13189",
language = "English",
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journal = "European Journal of Cancer Care",
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publisher = "Wiley-Blackwell",
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TY - JOUR

T1 - Patient self-testing of white blood cell count and differentiation: A study of feasibility and measurement performance in a population of Danish cancer patients

AU - Otto Mattsson, Thea

AU - Lindhardt, Christina Louise

AU - Schöley, Jonas

AU - Friis-Hansen, Lennart

A2 - Herrstedt, Jørn

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Objective: Patients in anticancer treatment with a known side effect of neutropenia are monitored closely with laboratory measurements of white blood cell count (WBC) and differentiation. This study sought to evaluate measurement properties and feasibility of patients' self-testing using a point-of-care testing (POCT) device. Methods: A prospective feasibility and measurement study comparing the standard measurement of cancer patients' WBC and neutrophil count with POCT measurements. The study included 60 outpatients and 22 inpatients from a department of oncology at a university hospital. Results: Patients successfully conducted 106 measurements using the POCT device. 46% of the patients were >70 years. Weighted Deming regression analysis showed minimal yet significant proportional bias between methods, with POCT increasingly underestimating both total WBC and neutrophils compared with the standard method the higher the count. Over 90% of patients reported they were willing and considered themselves able to use the POCT device at home. Conclusions: The instrument can be used for self-testing of post-anticancer leukopenia and has sufficient measurement precision for patient risk stratification. Patients are able and willing to conduct measurements including when in a situation of acute illness. Further studies are needed to confirm safety and value within patients’ own home.

AB - Objective: Patients in anticancer treatment with a known side effect of neutropenia are monitored closely with laboratory measurements of white blood cell count (WBC) and differentiation. This study sought to evaluate measurement properties and feasibility of patients' self-testing using a point-of-care testing (POCT) device. Methods: A prospective feasibility and measurement study comparing the standard measurement of cancer patients' WBC and neutrophil count with POCT measurements. The study included 60 outpatients and 22 inpatients from a department of oncology at a university hospital. Results: Patients successfully conducted 106 measurements using the POCT device. 46% of the patients were >70 years. Weighted Deming regression analysis showed minimal yet significant proportional bias between methods, with POCT increasingly underestimating both total WBC and neutrophils compared with the standard method the higher the count. Over 90% of patients reported they were willing and considered themselves able to use the POCT device at home. Conclusions: The instrument can be used for self-testing of post-anticancer leukopenia and has sufficient measurement precision for patient risk stratification. Patients are able and willing to conduct measurements including when in a situation of acute illness. Further studies are needed to confirm safety and value within patients’ own home.

KW - aged

KW - antineoplastic agents

KW - febrile neutropenia

KW - medical oncology

KW - patient comfort

KW - patient education

KW - point-of-care testing

U2 - 10.1111/ecc.13189

DO - 10.1111/ecc.13189

M3 - Journal article

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VL - 29

JO - European Journal of Cancer Care

JF - European Journal of Cancer Care

SN - 0961-5423

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