Paternal age and telomere length in twins: the germ stem cell selection paradigm

Jacob B Hjelmborg, Christine Dalgård, Massimo Mangino, Tim D Spector, Ulrich Halekoh, Sören Möller, Masayuki Kimura, Kent Horvath, Jeremy D Kark, Kaare Christensen, Kirsten O Kyvik, Abraham Aviv

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Abstract

Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an 'epigenetic' mechanism through which paternal age plays a role in telomere length regulation in humans. Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we show an increase in the resemblance of leukocyte telomere length between dizygotic twins of older fathers, which is not seen in monozygotic twins. This phenomenon might result from a paternal age-dependent germ stem cell selection process, whereby the selected stem cells have longer telomeres, are more homogenous with respect to telomere length, and share resistance to aging.

Original languageEnglish
JournalAging Cell
Volume14
Issue number4
Pages (from-to)701-703
ISSN1474-9718
DOIs
Publication statusPublished - Aug 2015

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Paternal Age
Telomere
Germ Cells
Fathers
Dizygotic Twins
Twin Studies
Monozygotic Twins
Epigenomics

Keywords

  • father's age
  • germ line
  • heritability
  • leukocytes
  • telomeres
  • twins

Cite this

Hjelmborg, Jacob B ; Dalgård, Christine ; Mangino, Massimo ; Spector, Tim D ; Halekoh, Ulrich ; Möller, Sören ; Kimura, Masayuki ; Horvath, Kent ; Kark, Jeremy D ; Christensen, Kaare ; Kyvik, Kirsten O ; Aviv, Abraham. / Paternal age and telomere length in twins : the germ stem cell selection paradigm. In: Aging Cell. 2015 ; Vol. 14, No. 4. pp. 701-703.
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Paternal age and telomere length in twins : the germ stem cell selection paradigm. / Hjelmborg, Jacob B; Dalgård, Christine; Mangino, Massimo; Spector, Tim D; Halekoh, Ulrich; Möller, Sören; Kimura, Masayuki; Horvath, Kent; Kark, Jeremy D; Christensen, Kaare; Kyvik, Kirsten O; Aviv, Abraham.

In: Aging Cell, Vol. 14, No. 4, 08.2015, p. 701-703.

Research output: Contribution to journalJournal articleResearchpeer-review

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AU - Hjelmborg, Jacob B

AU - Dalgård, Christine

AU - Mangino, Massimo

AU - Spector, Tim D

AU - Halekoh, Ulrich

AU - Möller, Sören

AU - Kimura, Masayuki

AU - Horvath, Kent

AU - Kark, Jeremy D

AU - Christensen, Kaare

AU - Kyvik, Kirsten O

AU - Aviv, Abraham

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