Parental ethnicity associated with risk for multiple sclerosis: A population-based incident case–control study in Iran

Ibrahim Abdollahpour*, Saharnaz Nedjat, Mohammad Ali Mansournia, Mohammad Ali Sahraian, Nasrin Asgari

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: The epidemiology of multiple sclerosis (MS) includes a consideration of geography and population ethnicity. To determine whether there is any association between ethnicity and risk of MS in a multiethnic, population-based case–control study. Methods: We conducted a population-based case–control of 547 incident MS cases and 1057 healthy controls between August 2013 and February 2015, Tehran, a multi-ethnic city. The patients were identified and enrolled through the Iranian MS Society. Case status was confirmed by a panel of MS specialists beside of 2010 McDonald criteria. Controls were selected through random digit dialing. A logistic regression model was applied to estimate the odds ratios (95%CI) adjusted for age, sex, tobacco smoking and socioeconomic status. Results: The risk of MS for Kurd, Turk and Fars ethnicities was apparently smaller compared to one specific ethnic background (Lor); OR 0.36 (0.15–0.86) for Kurd, OR 0.42 (0.24–0.74) for Turk and OR 0.53 (0.31–0.89) for Fars. Heterogeneity in parental ethnicity of common ethnic groups was significantly associated with increased risk of MS OR 1.61 (1.13–2.29). All associations remained after adjustment for relevant confounders. Conclusions: MS was unequally distributed in the ethnic groups. Moreover, heterogeneity in parental ethnicity seems to be a risk factor for MS.

Original languageEnglish
JournalMultiple Sclerosis and Related Disorders
Volume20
Pages (from-to)100-103
ISSN2211-0348
DOIs
Publication statusPublished - Feb 2018

Fingerprint

Iran
Population
Logistic Models
Geography
Epidemiology
Smoking
Odds Ratio

Keywords

  • Ethnicity
  • Heterogeneity in parental ethnicity
  • Iran
  • Logistic regression
  • Multiple sclerosis
  • Population-based incident case-control
  • Genetic Predisposition to Disease
  • Humans
  • Middle Aged
  • Risk Factors
  • Parents
  • Logistic Models
  • Male
  • Case-Control Studies
  • Genetic Heterogeneity
  • Young Adult
  • Multiple Sclerosis/ethnology
  • Adolescent
  • Adult
  • Female
  • Odds Ratio
  • Iran/epidemiology

Cite this

Abdollahpour, Ibrahim ; Nedjat, Saharnaz ; Mansournia, Mohammad Ali ; Sahraian, Mohammad Ali ; Asgari, Nasrin. / Parental ethnicity associated with risk for multiple sclerosis : A population-based incident case–control study in Iran. In: Multiple Sclerosis and Related Disorders. 2018 ; Vol. 20. pp. 100-103.
@article{d931c2ec811945cd8194e96c8031470f,
title = "Parental ethnicity associated with risk for multiple sclerosis: A population-based incident case–control study in Iran",
abstract = "Background: The epidemiology of multiple sclerosis (MS) includes a consideration of geography and population ethnicity. To determine whether there is any association between ethnicity and risk of MS in a multiethnic, population-based case–control study. Methods: We conducted a population-based case–control of 547 incident MS cases and 1057 healthy controls between August 2013 and February 2015, Tehran, a multi-ethnic city. The patients were identified and enrolled through the Iranian MS Society. Case status was confirmed by a panel of MS specialists beside of 2010 McDonald criteria. Controls were selected through random digit dialing. A logistic regression model was applied to estimate the odds ratios (95{\%}CI) adjusted for age, sex, tobacco smoking and socioeconomic status. Results: The risk of MS for Kurd, Turk and Fars ethnicities was apparently smaller compared to one specific ethnic background (Lor); OR 0.36 (0.15–0.86) for Kurd, OR 0.42 (0.24–0.74) for Turk and OR 0.53 (0.31–0.89) for Fars. Heterogeneity in parental ethnicity of common ethnic groups was significantly associated with increased risk of MS OR 1.61 (1.13–2.29). All associations remained after adjustment for relevant confounders. Conclusions: MS was unequally distributed in the ethnic groups. Moreover, heterogeneity in parental ethnicity seems to be a risk factor for MS.",
keywords = "Ethnicity, Heterogeneity in parental ethnicity, Iran, Logistic regression, Multiple sclerosis, Population-based incident case-control, Genetic Predisposition to Disease, Humans, Middle Aged, Risk Factors, Parents, Logistic Models, Male, Case-Control Studies, Genetic Heterogeneity, Young Adult, Multiple Sclerosis/ethnology, Adolescent, Adult, Female, Odds Ratio, Iran/epidemiology",
author = "Ibrahim Abdollahpour and Saharnaz Nedjat and Mansournia, {Mohammad Ali} and Sahraian, {Mohammad Ali} and Nasrin Asgari",
year = "2018",
month = "2",
doi = "10.1016/j.msard.2018.01.008",
language = "English",
volume = "20",
pages = "100--103",
journal = "Multiple Sclerosis and Related Disorders",
issn = "2211-0348",
publisher = "Elsevier",

}

Parental ethnicity associated with risk for multiple sclerosis : A population-based incident case–control study in Iran. / Abdollahpour, Ibrahim; Nedjat, Saharnaz; Mansournia, Mohammad Ali; Sahraian, Mohammad Ali; Asgari, Nasrin.

In: Multiple Sclerosis and Related Disorders, Vol. 20, 02.2018, p. 100-103.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Parental ethnicity associated with risk for multiple sclerosis

T2 - A population-based incident case–control study in Iran

AU - Abdollahpour, Ibrahim

AU - Nedjat, Saharnaz

AU - Mansournia, Mohammad Ali

AU - Sahraian, Mohammad Ali

AU - Asgari, Nasrin

PY - 2018/2

Y1 - 2018/2

N2 - Background: The epidemiology of multiple sclerosis (MS) includes a consideration of geography and population ethnicity. To determine whether there is any association between ethnicity and risk of MS in a multiethnic, population-based case–control study. Methods: We conducted a population-based case–control of 547 incident MS cases and 1057 healthy controls between August 2013 and February 2015, Tehran, a multi-ethnic city. The patients were identified and enrolled through the Iranian MS Society. Case status was confirmed by a panel of MS specialists beside of 2010 McDonald criteria. Controls were selected through random digit dialing. A logistic regression model was applied to estimate the odds ratios (95%CI) adjusted for age, sex, tobacco smoking and socioeconomic status. Results: The risk of MS for Kurd, Turk and Fars ethnicities was apparently smaller compared to one specific ethnic background (Lor); OR 0.36 (0.15–0.86) for Kurd, OR 0.42 (0.24–0.74) for Turk and OR 0.53 (0.31–0.89) for Fars. Heterogeneity in parental ethnicity of common ethnic groups was significantly associated with increased risk of MS OR 1.61 (1.13–2.29). All associations remained after adjustment for relevant confounders. Conclusions: MS was unequally distributed in the ethnic groups. Moreover, heterogeneity in parental ethnicity seems to be a risk factor for MS.

AB - Background: The epidemiology of multiple sclerosis (MS) includes a consideration of geography and population ethnicity. To determine whether there is any association between ethnicity and risk of MS in a multiethnic, population-based case–control study. Methods: We conducted a population-based case–control of 547 incident MS cases and 1057 healthy controls between August 2013 and February 2015, Tehran, a multi-ethnic city. The patients were identified and enrolled through the Iranian MS Society. Case status was confirmed by a panel of MS specialists beside of 2010 McDonald criteria. Controls were selected through random digit dialing. A logistic regression model was applied to estimate the odds ratios (95%CI) adjusted for age, sex, tobacco smoking and socioeconomic status. Results: The risk of MS for Kurd, Turk and Fars ethnicities was apparently smaller compared to one specific ethnic background (Lor); OR 0.36 (0.15–0.86) for Kurd, OR 0.42 (0.24–0.74) for Turk and OR 0.53 (0.31–0.89) for Fars. Heterogeneity in parental ethnicity of common ethnic groups was significantly associated with increased risk of MS OR 1.61 (1.13–2.29). All associations remained after adjustment for relevant confounders. Conclusions: MS was unequally distributed in the ethnic groups. Moreover, heterogeneity in parental ethnicity seems to be a risk factor for MS.

KW - Ethnicity

KW - Heterogeneity in parental ethnicity

KW - Iran

KW - Logistic regression

KW - Multiple sclerosis

KW - Population-based incident case-control

KW - Genetic Predisposition to Disease

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Parents

KW - Logistic Models

KW - Male

KW - Case-Control Studies

KW - Genetic Heterogeneity

KW - Young Adult

KW - Multiple Sclerosis/ethnology

KW - Adolescent

KW - Adult

KW - Female

KW - Odds Ratio

KW - Iran/epidemiology

U2 - 10.1016/j.msard.2018.01.008

DO - 10.1016/j.msard.2018.01.008

M3 - Journal article

C2 - 29353734

AN - SCOPUS:85041392279

VL - 20

SP - 100

EP - 103

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

ER -