Parallel RNA-strand recognition by 2'-amino-β-LNA

T. Santhosh Kumar; Michael E. Østergaard; Pawan K. Sharma; Poul Nielsen; Jesper Wengel; Patrick J. Hrdlicka

doi:10.1016/j.bmcl.2009.03.079

Parallel RNA-strand recognition by 2'-amino-β-LNA

T. Santhosh Kumar
, Michael E. Østergaard
, Pawan K. Sharma
, Poul Nielsen
, Jesper Wengel
, Patrick J. Hrdlicka

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.

Original language	English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	19
Issue number	9
Pages (from-to)	2396-2399
Number of pages	4
ISSN	0960-894X
DOIs	https://doi.org/10.1016/j.bmcl.2009.03.079
Publication status	Published - 2009

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@article{d6e0cc206af211de9c46000ea68e967b,

title = "Parallel RNA-strand recognition by 2'-amino-β-LNA",

abstract = "A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.",

author = "Kumar, \{T. Santhosh\} and {\O}stergaard, \{Michael E.\} and Sharma, \{Pawan K.\} and Poul Nielsen and Jesper Wengel and Hrdlicka, \{Patrick J.\}",

year = "2009",

doi = "10.1016/j.bmcl.2009.03.079",

language = "English",

volume = "19",

pages = "2396--2399",

journal = "Bioorganic \& Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - Parallel RNA-strand recognition by 2'-amino-β-LNA

AU - Kumar, T. Santhosh

AU - Østergaard, Michael E.

AU - Sharma, Pawan K.

AU - Nielsen, Poul

AU - Wengel, Jesper

AU - Hrdlicka, Patrick J.

PY - 2009

Y1 - 2009

N2 - A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.

AB - A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.

U2 - 10.1016/j.bmcl.2009.03.079

DO - 10.1016/j.bmcl.2009.03.079

M3 - Journal article

SN - 0960-894X

VL - 19

SP - 2396

EP - 2399

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 9

ER -

Parallel RNA-strand recognition by 2'-amino-β-LNA

Abstract

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