Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

Pierre J Marie, Moustapha Kassem

Research output: Contribution to journalJournal articleResearchpeer-review


Age-related bone loss is associated with significant changes in bone remodeling characterized by decreased trabecular and periosteal bone formation relative to bone resorption, resulting in bone fragility and increased risk of fractures. Prevention or reversal of age-related decrease in bone mass and increase in bone fragility has been based on inhibition of bone resorption using anticatabolic drugs. The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration.
Original languageEnglish
JournalEuropean Journal of Endocrinology
Issue number1
Pages (from-to)1-10
Number of pages10
Publication statusPublished - 2011


  • Aging
  • Anabolic Agents
  • Animals
  • Bone Morphogenetic Proteins
  • Bone Resorption
  • Female
  • Genetic Markers
  • Growth Hormone
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Insulin-Like Growth Factor I
  • Osteoblasts
  • Osteogenesis
  • Osteoporosis
  • Parathyroid Hormone
  • Receptors, Calcium-Sensing
  • Signal Transduction
  • Transforming Growth Factor beta1
  • Wnt Proteins
  • beta Catenin


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