Osteoblastic cells: differentiation and trans-differentiation

Moustapha Kassem, Basem Abdallah, Hamid Saeed

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation.
Original languageEnglish
JournalArchives of Biochemistry and Biophysics
Volume473
Issue number2
Pages (from-to)183-7
Number of pages4
ISSN0003-9861
DOIs
Publication statusPublished - 15. May 2008

Fingerprint

Osteoblasts
Cell Differentiation
Mesenchymal Stromal Cells
Mesoderm
Adipocytes
Osteogenesis
Maintenance

Keywords

  • Adipocytes
  • Animals
  • Bone Marrow Cells
  • Cell Differentiation
  • Cell Lineage
  • Humans
  • Mesenchymal Stem Cells
  • Osteoblasts
  • Osteogenesis

Cite this

Kassem, Moustapha ; Abdallah, Basem ; Saeed, Hamid. / Osteoblastic cells: differentiation and trans-differentiation. In: Archives of Biochemistry and Biophysics. 2008 ; Vol. 473, No. 2. pp. 183-7.
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Osteoblastic cells: differentiation and trans-differentiation. / Kassem, Moustapha; Abdallah, Basem; Saeed, Hamid.

In: Archives of Biochemistry and Biophysics, Vol. 473, No. 2, 15.05.2008, p. 183-7.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Osteoblastic cells: differentiation and trans-differentiation

AU - Kassem, Moustapha

AU - Abdallah, Basem

AU - Saeed, Hamid

PY - 2008/5/15

Y1 - 2008/5/15

N2 - The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation.

AB - The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation.

KW - Adipocytes

KW - Animals

KW - Bone Marrow Cells

KW - Cell Differentiation

KW - Cell Lineage

KW - Humans

KW - Mesenchymal Stem Cells

KW - Osteoblasts

KW - Osteogenesis

U2 - 10.1016/j.abb.2008.03.028

DO - 10.1016/j.abb.2008.03.028

M3 - Journal article

VL - 473

SP - 183

EP - 187

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

SN - 0003-9861

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ER -