Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats

M Feigh; K V Andreassen; A V Neutzsky-Wulff; S T Petersen; C Hansen; Anne-Christine Bay Jensen; J E Henriksen; H Beck-Nielsen; C Christiansen; K Henriksen; M A Karsdal

doi:10.1111/j.1476-5381.2012.01979.x

Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats

M Feigh
, K V Andreassen
, A V Neutzsky-Wulff
, S T Petersen
, C Hansen
, Anne-Christine Bay Jensen
, J E Henriksen
, H Beck-Nielsen
, C Christiansen
, K Henriksen
, M A Karsdal

KI, OUH, Research unit of Endocrinology (Odense)

Nordic Bioscience

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Oral salmon calcitonin (sCT), a dual-action amylin and calcitonin receptor agonist, improved glucose homeostasis in diet-induced obese rats. Here, we have evaluated the anti-diabetic efficacy of oral sCT using parameters of glycaemic control and beta-cell morphology in male Zucker diabetic fatty (ZDF) rats, a model of type 2 diabetes.

Original language	English
Journal	British Journal of Pharmacology
Volume	167
Issue number	1
Pages (from-to)	151-63
Number of pages	13
ISSN	0007-1188
DOIs	https://doi.org/10.1111/j.1476-5381.2012.01979.x
Publication status	Published - 2012

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Feigh, M., Andreassen, K. V., Neutzsky-Wulff, A. V., Petersen, S. T., Hansen, C., Jensen, A.-C. B., Henriksen, J. E., Beck-Nielsen, H., Christiansen, C., Henriksen, K., & Karsdal, M. A. (2012). Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats. British Journal of Pharmacology, 167(1), 151-63. https://doi.org/10.1111/j.1476-5381.2012.01979.x

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title = "Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats",

abstract = "Oral salmon calcitonin (sCT), a dual-action amylin and calcitonin receptor agonist, improved glucose homeostasis in diet-induced obese rats. Here, we have evaluated the anti-diabetic efficacy of oral sCT using parameters of glycaemic control and beta-cell morphology in male Zucker diabetic fatty (ZDF) rats, a model of type 2 diabetes.",

author = "M Feigh and Andreassen, \{K V\} and Neutzsky-Wulff, \{A V\} and Petersen, \{S T\} and C Hansen and Jensen, \{Anne-Christine Bay\} and Henriksen, \{J E\} and H Beck-Nielsen and C Christiansen and K Henriksen and Karsdal, \{M A\}",

note = "{\textcopyright} 2012 Nordic Bioscience. British Journal of Pharmacology {\textcopyright} 2012 The British Pharmacological Society.",

year = "2012",

doi = "10.1111/j.1476-5381.2012.01979.x",

language = "English",

volume = "167",

pages = "151--63",

journal = "British Journal of Pharmacology",

issn = "0007-1188",

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Feigh, M, Andreassen, KV, Neutzsky-Wulff, AV, Petersen, ST, Hansen, C, Jensen, A-CB, Henriksen, JE , Beck-Nielsen, H, Christiansen, C, Henriksen, K & Karsdal, MA 2012, 'Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats', British Journal of Pharmacology, vol. 167, no. 1, pp. 151-63. https://doi.org/10.1111/j.1476-5381.2012.01979.x

TY - JOUR

T1 - Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats

AU - Feigh, M

AU - Andreassen, K V

AU - Neutzsky-Wulff, A V

AU - Petersen, S T

AU - Hansen, C

AU - Jensen, Anne-Christine Bay

AU - Henriksen, J E

AU - Beck-Nielsen, H

AU - Christiansen, C

AU - Henriksen, K

AU - Karsdal, M A

PY - 2012

Y1 - 2012

N2 - Oral salmon calcitonin (sCT), a dual-action amylin and calcitonin receptor agonist, improved glucose homeostasis in diet-induced obese rats. Here, we have evaluated the anti-diabetic efficacy of oral sCT using parameters of glycaemic control and beta-cell morphology in male Zucker diabetic fatty (ZDF) rats, a model of type 2 diabetes.

AB - Oral salmon calcitonin (sCT), a dual-action amylin and calcitonin receptor agonist, improved glucose homeostasis in diet-induced obese rats. Here, we have evaluated the anti-diabetic efficacy of oral sCT using parameters of glycaemic control and beta-cell morphology in male Zucker diabetic fatty (ZDF) rats, a model of type 2 diabetes.

U2 - 10.1111/j.1476-5381.2012.01979.x

DO - 10.1111/j.1476-5381.2012.01979.x

M3 - Journal article

C2 - 22506938

SN - 0007-1188

VL - 167

SP - 151

EP - 163

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 1

ER -

Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats

Abstract

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