One or two day mifepristone-misoprostol interval for second trimester abortion

Lisbeth Nilas, Marianne Glavind-Kristensen, Thomas Vejborg, Ulla Breth Knudsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

METHODS: A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h. RESULTS: The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98% within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001). CONCLUSION: The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care.
Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Volume86
Issue number9
Pages (from-to)1117-1121
Number of pages4
ISSN0001-6349
DOIs
Publication statusPublished - 2007

Fingerprint

Misoprostol
Mifepristone
Second Pregnancy Trimester
Fetus
Cohort Studies
Pharmaceutical Preparations

Keywords

  • Abortifacient Agents, Nonsteroidal
  • Abortifacient Agents, Steroidal
  • Abortion, Induced
  • Administration, Intravaginal
  • Administration, Oral
  • Adult
  • Cohort Studies
  • Female
  • Gestational Age
  • Gravidity
  • Humans
  • Mifepristone
  • Misoprostol
  • Parity
  • Pregnancy
  • Pregnancy Trimester, Second
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome

Cite this

Nilas, Lisbeth ; Glavind-Kristensen, Marianne ; Vejborg, Thomas ; Knudsen, Ulla Breth. / One or two day mifepristone-misoprostol interval for second trimester abortion. In: Acta Obstetricia et Gynecologica Scandinavica. 2007 ; Vol. 86, No. 9. pp. 1117-1121.
@article{942d7570c9ab11dc8674000ea68e967b,
title = "One or two day mifepristone-misoprostol interval for second trimester abortion",
abstract = "METHODS: A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h. RESULTS: The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98{\%} within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001). CONCLUSION: The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care.",
keywords = "Abortifacient Agents, Nonsteroidal, Abortifacient Agents, Steroidal, Abortion, Induced, Administration, Intravaginal, Administration, Oral, Adult, Cohort Studies, Female, Gestational Age, Gravidity, Humans, Mifepristone, Misoprostol, Parity, Pregnancy, Pregnancy Trimester, Second, Retrospective Studies, Time Factors, Treatment Outcome",
author = "Lisbeth Nilas and Marianne Glavind-Kristensen and Thomas Vejborg and Knudsen, {Ulla Breth}",
year = "2007",
doi = "10.1080/00016340701505002",
language = "English",
volume = "86",
pages = "1117--1121",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
publisher = "JohnWiley & Sons Ltd.",
number = "9",

}

One or two day mifepristone-misoprostol interval for second trimester abortion. / Nilas, Lisbeth; Glavind-Kristensen, Marianne; Vejborg, Thomas; Knudsen, Ulla Breth.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 86, No. 9, 2007, p. 1117-1121.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - One or two day mifepristone-misoprostol interval for second trimester abortion

AU - Nilas, Lisbeth

AU - Glavind-Kristensen, Marianne

AU - Vejborg, Thomas

AU - Knudsen, Ulla Breth

PY - 2007

Y1 - 2007

N2 - METHODS: A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h. RESULTS: The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98% within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001). CONCLUSION: The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care.

AB - METHODS: A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h. RESULTS: The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98% within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001). CONCLUSION: The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care.

KW - Abortifacient Agents, Nonsteroidal

KW - Abortifacient Agents, Steroidal

KW - Abortion, Induced

KW - Administration, Intravaginal

KW - Administration, Oral

KW - Adult

KW - Cohort Studies

KW - Female

KW - Gestational Age

KW - Gravidity

KW - Humans

KW - Mifepristone

KW - Misoprostol

KW - Parity

KW - Pregnancy

KW - Pregnancy Trimester, Second

KW - Retrospective Studies

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1080/00016340701505002

DO - 10.1080/00016340701505002

M3 - Journal article

C2 - 17712654

VL - 86

SP - 1117

EP - 1121

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 9

ER -