Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections

Rune M Pedersen; Line L Bang; Ditte S Tornby; Lone W Madsen; Dorte K Holm; Thomas V Sydenham; Isik S Johansen; Thøger G Jensen; Ulrik S Justesen; Thomas E Andersen

doi:10.3201/eid2812.221304

Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections

Rune M Pedersen, Line L Bang, Ditte S Tornby, Lone W Madsen, Dorte K Holm, Thomas V Sydenham, Isik S Johansen, Thøger G Jensen, Ulrik S Justesen, Thomas E Andersen

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Abstract

Worldwide, millions of persons have received multiple COVID-19 vaccinations and subsequently recovered from SARS-CoV-2 Omicron breakthrough infections. In 2 small, matched cohorts (n = 12, n = 24) in Denmark, we found Omicron BA.1/BA.2 breakthrough infection after 3-dose BNT162b2 vaccination provided improved Omicron BA.5 neutralization over 3-dose vaccination alone.

Original language	English
Journal	Emerging Infectious Diseases
Volume	28
Issue number	12
Pages (from-to)	2575-2577
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2812.221304
Publication status	Published - Dec 2022

Keywords

Humans
BNT162 Vaccine
COVID-19/prevention & control
SARS-CoV-2
Viral Vaccines
Vaccination
Antibodies, Viral
Antibodies, Neutralizing

Documents & Links

10.3201/eid2812.221304Licence: CC BY

Open Access VersionFinal published version, 551 KBLicence: CC BY

Cite this

@article{73da599066a74c908d1794675d483f90,

title = "Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections",

abstract = "Worldwide, millions of persons have received multiple COVID-19 vaccinations and subsequently recovered from SARS-CoV-2 Omicron breakthrough infections. In 2 small, matched cohorts (n = 12, n = 24) in Denmark, we found Omicron BA.1/BA.2 breakthrough infection after 3-dose BNT162b2 vaccination provided improved Omicron BA.5 neutralization over 3-dose vaccination alone.",

keywords = "Humans, BNT162 Vaccine, COVID-19/prevention & control, SARS-CoV-2, Viral Vaccines, Vaccination, Antibodies, Viral, Antibodies, Neutralizing",

author = "Pedersen, {Rune M} and Bang, {Line L} and Tornby, {Ditte S} and Madsen, {Lone W} and Holm, {Dorte K} and Sydenham, {Thomas V} and Johansen, {Isik S} and Jensen, {Th{\o}ger G} and Justesen, {Ulrik S} and Andersen, {Thomas E}",

year = "2022",

month = dec,

doi = "10.3201/eid2812.221304",

language = "English",

volume = "28",

pages = "2575--2577",

journal = "Emerging Infectious Diseases (Print Edition)",

issn = "1080-6040",

publisher = "CDC Centers for Disease Control and Prevention",

number = "12",

}

TY - JOUR

T1 - Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections

AU - Pedersen, Rune M

AU - Bang, Line L

AU - Tornby, Ditte S

AU - Madsen, Lone W

AU - Holm, Dorte K

AU - Sydenham, Thomas V

AU - Johansen, Isik S

AU - Jensen, Thøger G

AU - Justesen, Ulrik S

AU - Andersen, Thomas E

PY - 2022/12

Y1 - 2022/12

N2 - Worldwide, millions of persons have received multiple COVID-19 vaccinations and subsequently recovered from SARS-CoV-2 Omicron breakthrough infections. In 2 small, matched cohorts (n = 12, n = 24) in Denmark, we found Omicron BA.1/BA.2 breakthrough infection after 3-dose BNT162b2 vaccination provided improved Omicron BA.5 neutralization over 3-dose vaccination alone.

AB - Worldwide, millions of persons have received multiple COVID-19 vaccinations and subsequently recovered from SARS-CoV-2 Omicron breakthrough infections. In 2 small, matched cohorts (n = 12, n = 24) in Denmark, we found Omicron BA.1/BA.2 breakthrough infection after 3-dose BNT162b2 vaccination provided improved Omicron BA.5 neutralization over 3-dose vaccination alone.

KW - Humans

KW - BNT162 Vaccine

KW - COVID-19/prevention & control

KW - SARS-CoV-2

KW - Viral Vaccines

KW - Vaccination

KW - Antibodies, Viral

KW - Antibodies, Neutralizing

U2 - 10.3201/eid2812.221304

DO - 10.3201/eid2812.221304

M3 - Journal article

C2 - 36347270

VL - 28

SP - 2575

EP - 2577

JO - Emerging Infectious Diseases (Print Edition)

JF - Emerging Infectious Diseases (Print Edition)

SN - 1080-6040

IS - 12

ER -

Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections

Abstract

Keywords

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