Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

Kim Vejlegaard Kristensen, Sibasish Paul, Tamer Kosbar, Jesper Wengel, Marvin H Caruthers

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Abstract

Incorporation in a 2'→5' direction of a phosphorodiamidite 2'-amino-LNA-T nucleotide as the morpholino phosphoramidate and N,N-dimethylamino phosphorodiamidate monomers into six oligonucleotides is reported. Thermal denaturation studies showed that the novel 2'-amino-LNA-based morpholino monomers exert a destabilizing effects on duplexes formed with complementary DNA and RNA.

Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume27
Issue number14
Pages (from-to)3173–3176
ISSN0960-894X
DOIs
Publication statusPublished - 2017

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Morpholinos
Oligodeoxyribonucleotides
Nucleotides
Monomers
Complementary RNA
Denaturation
Oligonucleotides
Complementary DNA
amino-LNA
phosphoramidic acid
Hot Temperature
Direction compound

Keywords

  • Journal Article

Cite this

Kristensen, Kim Vejlegaard ; Paul, Sibasish ; Kosbar, Tamer ; Wengel, Jesper ; Caruthers, Marvin H. / Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers. In: Bioorganic & Medicinal Chemistry Letters. 2017 ; Vol. 27, No. 14. pp. 3173–3176.
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abstract = "Incorporation in a 2'→5' direction of a phosphorodiamidite 2'-amino-LNA-T nucleotide as the morpholino phosphoramidate and N,N-dimethylamino phosphorodiamidate monomers into six oligonucleotides is reported. Thermal denaturation studies showed that the novel 2'-amino-LNA-based morpholino monomers exert a destabilizing effects on duplexes formed with complementary DNA and RNA.",
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Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers. / Kristensen, Kim Vejlegaard; Paul, Sibasish; Kosbar, Tamer; Wengel, Jesper; Caruthers, Marvin H.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 27, No. 14, 2017, p. 3173–3176.

Research output: Contribution to journalLetterResearchpeer-review

TY - JOUR

T1 - Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

AU - Kristensen, Kim Vejlegaard

AU - Paul, Sibasish

AU - Kosbar, Tamer

AU - Wengel, Jesper

AU - Caruthers, Marvin H

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017

Y1 - 2017

N2 - Incorporation in a 2'→5' direction of a phosphorodiamidite 2'-amino-LNA-T nucleotide as the morpholino phosphoramidate and N,N-dimethylamino phosphorodiamidate monomers into six oligonucleotides is reported. Thermal denaturation studies showed that the novel 2'-amino-LNA-based morpholino monomers exert a destabilizing effects on duplexes formed with complementary DNA and RNA.

AB - Incorporation in a 2'→5' direction of a phosphorodiamidite 2'-amino-LNA-T nucleotide as the morpholino phosphoramidate and N,N-dimethylamino phosphorodiamidate monomers into six oligonucleotides is reported. Thermal denaturation studies showed that the novel 2'-amino-LNA-based morpholino monomers exert a destabilizing effects on duplexes formed with complementary DNA and RNA.

KW - Journal Article

U2 - 10.1016/j.bmcl.2017.05.023

DO - 10.1016/j.bmcl.2017.05.023

M3 - Letter

C2 - 28552336

VL - 27

SP - 3173

EP - 3176

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 14

ER -