Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort

An ECCO-EpiCom study

Johan Burisch, Zsuzsanna Vegh, Konstantinnos H Katsanos, Dimitrios K Christodoulou, Daniela Lazar, Adrian Goldis, Colm O'Morain, Alberto Fernandez, Santos Pereira, Sally Myers, Shaji Sebastian, Natalia Pedersen, Jóngerð Olsen, Kári Rubek Nielsen, Doron Schwartz, Selwyn Odes, Sven Almer, Jonas Halfvarson, Niksa Turk, Silvja Cukovic-Cavka & 31 others Inna Nikulina, Elena Belousova, Dana Duricova, Martin Bortlik, Olga Shonová, Riina Salupere, Louisa Barros, Fernando Magro, Laimas Jonaitis, Limas Kupcinskas, Svetlana Turcan, Ioannis Kaimakliotis, Karin Ladefoged, Karen Kudsk, Vibeke Andersen, Ida Vind, Niels Thorsgaard, Pia Oksanen, Pekka Collin, Giulia Dal Piaz, Alessia Santini, Ola Niewiadomski, Sally Bell, Bjørn Moum, Naila Arebi, Jens Kjeldsen, Katrine Carlsen, Ebbe Langholz, Peter Laszlo Lakatos, Lars Ulrik Gerdes, EpiCom Group

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Abstract

Background and aims: Anaemia is an important complication of inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of anaemia and the practice of anaemia screening during the first year following diagnosis in a European prospective population-based inception cohort.

Methods: Newly diagnosed IBD patients were included and followed prospectively for one year in 29 European and 1 Australian centre. Clinical data including demographics, medical therapy, surgery and blood samples were collected. Anaemia was defined according to the World Health Organization.

Results: A total of 1,871 patients (CD: 686, 88%; UC: 1,021, 87%; IBDU 164. 81%) were included in the study. The prevalence of anaemia was higher in CD than in UC patients and overall, 49% of CD and 39% of UC patients had at least one instance of anaemia during the first 12 months after diagnosis. UC patients with more extensive disease and those from Eastern European countries, and CD patients with penetrating disease or colonic disease location, had higher risks of anaemia. CD and UC patients in need of none or only mild anti-inflammatory treatment had a lower risk of anaemia. In a significant proportion of patients, anaemia was not assessed until several months after diagnosis, and in almost half of all cases of anaemia a thorough work-up was not performed.

Conclusions: Overall, 42% of patients had at least one instance of anaemia during the first year following diagnosis. Most patients were assessed for anaemia regularly; however, a full anaemia work-up was frequently neglected in this community setting.

Original languageEnglish
JournalJournal of Crohn's and Colitis
Volume11
Issue number10
Pages (from-to)1213–1222
ISSN1873-9946
DOIs
Publication statusPublished - 2017

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Inflammatory Bowel Diseases
Population
Colonic Diseases

Keywords

  • Journal Article

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Burisch, Johan ; Vegh, Zsuzsanna ; Katsanos, Konstantinnos H ; Christodoulou, Dimitrios K ; Lazar, Daniela ; Goldis, Adrian ; O'Morain, Colm ; Fernandez, Alberto ; Pereira, Santos ; Myers, Sally ; Sebastian, Shaji ; Pedersen, Natalia ; Olsen, Jóngerð ; Nielsen, Kári Rubek ; Schwartz, Doron ; Odes, Selwyn ; Almer, Sven ; Halfvarson, Jonas ; Turk, Niksa ; Cukovic-Cavka, Silvja ; Nikulina, Inna ; Belousova, Elena ; Duricova, Dana ; Bortlik, Martin ; Shonová, Olga ; Salupere, Riina ; Barros, Louisa ; Magro, Fernando ; Jonaitis, Laimas ; Kupcinskas, Limas ; Turcan, Svetlana ; Kaimakliotis, Ioannis ; Ladefoged, Karin ; Kudsk, Karen ; Andersen, Vibeke ; Vind, Ida ; Thorsgaard, Niels ; Oksanen, Pia ; Collin, Pekka ; Dal Piaz, Giulia ; Santini, Alessia ; Niewiadomski, Ola ; Bell, Sally ; Moum, Bjørn ; Arebi, Naila ; Kjeldsen, Jens ; Carlsen, Katrine ; Langholz, Ebbe ; Lakatos, Peter Laszlo ; Gerdes, Lars Ulrik ; EpiCom Group. / Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort : An ECCO-EpiCom study. In: Journal of Crohn's and Colitis. 2017 ; Vol. 11, No. 10. pp. 1213–1222.
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title = "Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort: An ECCO-EpiCom study",
abstract = "Background and aims: Anaemia is an important complication of inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of anaemia and the practice of anaemia screening during the first year following diagnosis in a European prospective population-based inception cohort.Methods: Newly diagnosed IBD patients were included and followed prospectively for one year in 29 European and 1 Australian centre. Clinical data including demographics, medical therapy, surgery and blood samples were collected. Anaemia was defined according to the World Health Organization.Results: A total of 1,871 patients (CD: 686, 88{\%}; UC: 1,021, 87{\%}; IBDU 164. 81{\%}) were included in the study. The prevalence of anaemia was higher in CD than in UC patients and overall, 49{\%} of CD and 39{\%} of UC patients had at least one instance of anaemia during the first 12 months after diagnosis. UC patients with more extensive disease and those from Eastern European countries, and CD patients with penetrating disease or colonic disease location, had higher risks of anaemia. CD and UC patients in need of none or only mild anti-inflammatory treatment had a lower risk of anaemia. In a significant proportion of patients, anaemia was not assessed until several months after diagnosis, and in almost half of all cases of anaemia a thorough work-up was not performed.Conclusions: Overall, 42{\%} of patients had at least one instance of anaemia during the first year following diagnosis. Most patients were assessed for anaemia regularly; however, a full anaemia work-up was frequently neglected in this community setting.",
keywords = "Journal Article",
author = "Johan Burisch and Zsuzsanna Vegh and Katsanos, {Konstantinnos H} and Christodoulou, {Dimitrios K} and Daniela Lazar and Adrian Goldis and Colm O'Morain and Alberto Fernandez and Santos Pereira and Sally Myers and Shaji Sebastian and Natalia Pedersen and J{\'o}nger{\dh} Olsen and Nielsen, {K{\'a}ri Rubek} and Doron Schwartz and Selwyn Odes and Sven Almer and Jonas Halfvarson and Niksa Turk and Silvja Cukovic-Cavka and Inna Nikulina and Elena Belousova and Dana Duricova and Martin Bortlik and Olga Shonov{\'a} and Riina Salupere and Louisa Barros and Fernando Magro and Laimas Jonaitis and Limas Kupcinskas and Svetlana Turcan and Ioannis Kaimakliotis and Karin Ladefoged and Karen Kudsk and Vibeke Andersen and Ida Vind and Niels Thorsgaard and Pia Oksanen and Pekka Collin and {Dal Piaz}, Giulia and Alessia Santini and Ola Niewiadomski and Sally Bell and Bj{\o}rn Moum and Naila Arebi and Jens Kjeldsen and Katrine Carlsen and Ebbe Langholz and Lakatos, {Peter Laszlo} and Gerdes, {Lars Ulrik} and {EpiCom Group}",
year = "2017",
doi = "10.1093/ecco-jcc/jjx077",
language = "English",
volume = "11",
pages = "1213–1222",
journal = "Journal of Crohn's and Colitis",
issn = "1873-9946",
publisher = "Heinemann",
number = "10",

}

Burisch, J, Vegh, Z, Katsanos, KH, Christodoulou, DK, Lazar, D, Goldis, A, O'Morain, C, Fernandez, A, Pereira, S, Myers, S, Sebastian, S, Pedersen, N, Olsen, J, Nielsen, KR, Schwartz, D, Odes, S, Almer, S, Halfvarson, J, Turk, N, Cukovic-Cavka, S, Nikulina, I, Belousova, E, Duricova, D, Bortlik, M, Shonová, O, Salupere, R, Barros, L, Magro, F, Jonaitis, L, Kupcinskas, L, Turcan, S, Kaimakliotis, I, Ladefoged, K, Kudsk, K, Andersen, V, Vind, I, Thorsgaard, N, Oksanen, P, Collin, P, Dal Piaz, G, Santini, A, Niewiadomski, O, Bell, S, Moum, B, Arebi, N, Kjeldsen, J, Carlsen, K, Langholz, E, Lakatos, PL, Gerdes, LU & EpiCom Group 2017, 'Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort: An ECCO-EpiCom study', Journal of Crohn's and Colitis, vol. 11, no. 10, pp. 1213–1222. https://doi.org/10.1093/ecco-jcc/jjx077

Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort : An ECCO-EpiCom study. / Burisch, Johan; Vegh, Zsuzsanna; Katsanos, Konstantinnos H; Christodoulou, Dimitrios K; Lazar, Daniela; Goldis, Adrian; O'Morain, Colm; Fernandez, Alberto; Pereira, Santos; Myers, Sally; Sebastian, Shaji; Pedersen, Natalia; Olsen, Jóngerð; Nielsen, Kári Rubek; Schwartz, Doron; Odes, Selwyn; Almer, Sven; Halfvarson, Jonas; Turk, Niksa; Cukovic-Cavka, Silvja; Nikulina, Inna; Belousova, Elena; Duricova, Dana; Bortlik, Martin; Shonová, Olga; Salupere, Riina; Barros, Louisa; Magro, Fernando; Jonaitis, Laimas; Kupcinskas, Limas; Turcan, Svetlana; Kaimakliotis, Ioannis; Ladefoged, Karin; Kudsk, Karen; Andersen, Vibeke; Vind, Ida; Thorsgaard, Niels; Oksanen, Pia; Collin, Pekka; Dal Piaz, Giulia; Santini, Alessia; Niewiadomski, Ola; Bell, Sally; Moum, Bjørn; Arebi, Naila; Kjeldsen, Jens; Carlsen, Katrine; Langholz, Ebbe; Lakatos, Peter Laszlo; Gerdes, Lars Ulrik; EpiCom Group.

In: Journal of Crohn's and Colitis, Vol. 11, No. 10, 2017, p. 1213–1222.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort

T2 - An ECCO-EpiCom study

AU - Burisch, Johan

AU - Vegh, Zsuzsanna

AU - Katsanos, Konstantinnos H

AU - Christodoulou, Dimitrios K

AU - Lazar, Daniela

AU - Goldis, Adrian

AU - O'Morain, Colm

AU - Fernandez, Alberto

AU - Pereira, Santos

AU - Myers, Sally

AU - Sebastian, Shaji

AU - Pedersen, Natalia

AU - Olsen, Jóngerð

AU - Nielsen, Kári Rubek

AU - Schwartz, Doron

AU - Odes, Selwyn

AU - Almer, Sven

AU - Halfvarson, Jonas

AU - Turk, Niksa

AU - Cukovic-Cavka, Silvja

AU - Nikulina, Inna

AU - Belousova, Elena

AU - Duricova, Dana

AU - Bortlik, Martin

AU - Shonová, Olga

AU - Salupere, Riina

AU - Barros, Louisa

AU - Magro, Fernando

AU - Jonaitis, Laimas

AU - Kupcinskas, Limas

AU - Turcan, Svetlana

AU - Kaimakliotis, Ioannis

AU - Ladefoged, Karin

AU - Kudsk, Karen

AU - Andersen, Vibeke

AU - Vind, Ida

AU - Thorsgaard, Niels

AU - Oksanen, Pia

AU - Collin, Pekka

AU - Dal Piaz, Giulia

AU - Santini, Alessia

AU - Niewiadomski, Ola

AU - Bell, Sally

AU - Moum, Bjørn

AU - Arebi, Naila

AU - Kjeldsen, Jens

AU - Carlsen, Katrine

AU - Langholz, Ebbe

AU - Lakatos, Peter Laszlo

AU - Gerdes, Lars Ulrik

AU - EpiCom Group

PY - 2017

Y1 - 2017

N2 - Background and aims: Anaemia is an important complication of inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of anaemia and the practice of anaemia screening during the first year following diagnosis in a European prospective population-based inception cohort.Methods: Newly diagnosed IBD patients were included and followed prospectively for one year in 29 European and 1 Australian centre. Clinical data including demographics, medical therapy, surgery and blood samples were collected. Anaemia was defined according to the World Health Organization.Results: A total of 1,871 patients (CD: 686, 88%; UC: 1,021, 87%; IBDU 164. 81%) were included in the study. The prevalence of anaemia was higher in CD than in UC patients and overall, 49% of CD and 39% of UC patients had at least one instance of anaemia during the first 12 months after diagnosis. UC patients with more extensive disease and those from Eastern European countries, and CD patients with penetrating disease or colonic disease location, had higher risks of anaemia. CD and UC patients in need of none or only mild anti-inflammatory treatment had a lower risk of anaemia. In a significant proportion of patients, anaemia was not assessed until several months after diagnosis, and in almost half of all cases of anaemia a thorough work-up was not performed.Conclusions: Overall, 42% of patients had at least one instance of anaemia during the first year following diagnosis. Most patients were assessed for anaemia regularly; however, a full anaemia work-up was frequently neglected in this community setting.

AB - Background and aims: Anaemia is an important complication of inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of anaemia and the practice of anaemia screening during the first year following diagnosis in a European prospective population-based inception cohort.Methods: Newly diagnosed IBD patients were included and followed prospectively for one year in 29 European and 1 Australian centre. Clinical data including demographics, medical therapy, surgery and blood samples were collected. Anaemia was defined according to the World Health Organization.Results: A total of 1,871 patients (CD: 686, 88%; UC: 1,021, 87%; IBDU 164. 81%) were included in the study. The prevalence of anaemia was higher in CD than in UC patients and overall, 49% of CD and 39% of UC patients had at least one instance of anaemia during the first 12 months after diagnosis. UC patients with more extensive disease and those from Eastern European countries, and CD patients with penetrating disease or colonic disease location, had higher risks of anaemia. CD and UC patients in need of none or only mild anti-inflammatory treatment had a lower risk of anaemia. In a significant proportion of patients, anaemia was not assessed until several months after diagnosis, and in almost half of all cases of anaemia a thorough work-up was not performed.Conclusions: Overall, 42% of patients had at least one instance of anaemia during the first year following diagnosis. Most patients were assessed for anaemia regularly; however, a full anaemia work-up was frequently neglected in this community setting.

KW - Journal Article

U2 - 10.1093/ecco-jcc/jjx077

DO - 10.1093/ecco-jcc/jjx077

M3 - Journal article

VL - 11

SP - 1213

EP - 1222

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - 10

ER -