Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study

Martina Meszaros; Adam Domonkos Tarnoki; David Laszlo Tarnoki; Daniel Tamas Kovacs; Bianka Forgo; Jooyeon Lee; Joohon Sung; Jørgen Vestbo; Veronika Müller; Laszlo Kunos; Andras Bikov

doi:10.1111/jsr.12979

Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study

Martina Meszaros
, Adam Domonkos Tarnoki
, David Laszlo Tarnoki
, Daniel Tamas Kovacs
, Bianka Forgo
, Jooyeon Lee
, Joohon Sung
, Jørgen Vestbo
, Veronika Müller
, Laszlo Kunos
, Andras Bikov^*

^*Corresponding author for this work

Semmelweis University
Seoul National University
Wythenshawe Hospital
University of Manchester

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Obstructive sleep apnea is associated with an increased risk of hypertension, diabetes and dyslipidaemia. Both obstructive sleep apnea and its comorbidities are at least partly heritable, suggesting a common genetic background. Our aim was to analyse the heritability of the relationship between obstructive sleep apnea and its comorbidities using a twin study. Forty-seven monozygotic and 22 dizygotic adult twin pairs recruited from the Hungarian Twin Registry (mean age 51 ± 15 years) attended an overnight diagnostic sleep study. A medical history was taken, blood pressure was measured, and blood samples were taken for fasting glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and lipoprotein (a). To evaluate the heritability of obstructive sleep apnea and its comorbidities bivariate analysis was performed with an adjustment for age, gender, body mass index (BMI) and smoking after false discovery rate correction and following exclusion of patients on lipid-lowering and antidiabetic medications. There was a significant correlation between indices of obstructive sleep apnea severity, such as the apnea–hypopnea index, oxygen desaturation index and percentage of sleep time spent with oxygen saturation below 90%, as well as blood pressure, serum triglyceride, lipoprotein (a) and glucose levels (all p <.05). The bivariate analysis revealed a common genetic background for the correlations between serum triglyceride and the oxygen desaturation index (r =.63, p =.03), as well as percentage of sleep time spent with oxygen saturation below 90% (r =.58, p =.03). None of the other correlations were significantly genetically or environmentally determined. This twin study demonstrates that the co-occurrence of obstructive sleep apnea with hypertriglyceridaemia has a genetic influence and heritable factors play an important role in the pathogenesis of dyslipidaemia in obstructive sleep apnea.

Original language	English
Article number	e12979
Journal	Journal of Sleep Research
Volume	29
Issue number	4
ISSN	0962-1105
DOIs	https://doi.org/10.1111/jsr.12979
Publication status	Published - 1. Aug 2020
Externally published	Yes

Funding

The study was supported by Hungarian Respiratory Society grants to AB and DLT, as well as a Semmelweis University grant to LK. This publication was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences to AB. The authors are also grateful to Elektro‐Oxigén Inc. for providing polysomnographic devices, Mrs Monika Banlaky for her assistance in polysomnographic measurements and Mr Rhys Tudge for grammatical corrections. Erasmus+ grant supported the statistical analysis performed by members of the Seoul National University (Korean Healthy Twin Study). Andras Bikov and Jørgen Vestbo are supported by the NIHR Manchester BRC.

Keywords

diabetes mellitus
genetics
lipids
OSAHS
sleep disordered breathing
triacylglycerol

Documents & Links

10.1111/jsr.12979Licence: CC BY

SDU Link

Check access to the material in SDU Library's search engine

Cite this

@article{e7e57e818ada469caad5742a1ffda6be,

title = "Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study",

abstract = "Obstructive sleep apnea is associated with an increased risk of hypertension, diabetes and dyslipidaemia. Both obstructive sleep apnea and its comorbidities are at least partly heritable, suggesting a common genetic background. Our aim was to analyse the heritability of the relationship between obstructive sleep apnea and its comorbidities using a twin study. Forty-seven monozygotic and 22 dizygotic adult twin pairs recruited from the Hungarian Twin Registry (mean age 51 ± 15 years) attended an overnight diagnostic sleep study. A medical history was taken, blood pressure was measured, and blood samples were taken for fasting glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and lipoprotein (a). To evaluate the heritability of obstructive sleep apnea and its comorbidities bivariate analysis was performed with an adjustment for age, gender, body mass index (BMI) and smoking after false discovery rate correction and following exclusion of patients on lipid-lowering and antidiabetic medications. There was a significant correlation between indices of obstructive sleep apnea severity, such as the apnea{\textendash}hypopnea index, oxygen desaturation index and percentage of sleep time spent with oxygen saturation below 90\%, as well as blood pressure, serum triglyceride, lipoprotein (a) and glucose levels (all p <.05). The bivariate analysis revealed a common genetic background for the correlations between serum triglyceride and the oxygen desaturation index (r =.63, p =.03), as well as percentage of sleep time spent with oxygen saturation below 90\% (r =.58, p =.03). None of the other correlations were significantly genetically or environmentally determined. This twin study demonstrates that the co-occurrence of obstructive sleep apnea with hypertriglyceridaemia has a genetic influence and heritable factors play an important role in the pathogenesis of dyslipidaemia in obstructive sleep apnea.",

keywords = "diabetes mellitus, genetics, lipids, OSAHS, sleep disordered breathing, triacylglycerol",

author = "Martina Meszaros and Tarnoki, \{Adam Domonkos\} and Tarnoki, \{David Laszlo\} and Kovacs, \{Daniel Tamas\} and Bianka Forgo and Jooyeon Lee and Joohon Sung and J{\o}rgen Vestbo and Veronika M{\"u}ller and Laszlo Kunos and Andras Bikov",

year = "2020",

month = aug,

day = "1",

doi = "10.1111/jsr.12979",

language = "English",

volume = "29",

journal = "Journal of Sleep Research",

issn = "0962-1105",

publisher = "Wiley",

number = "4",

}

TY - JOUR

T1 - Obstructive sleep apnea and hypertriglyceridaemia share common genetic background

T2 - Results of a twin study

AU - Meszaros, Martina

AU - Tarnoki, Adam Domonkos

AU - Tarnoki, David Laszlo

AU - Kovacs, Daniel Tamas

AU - Forgo, Bianka

AU - Lee, Jooyeon

AU - Sung, Joohon

AU - Vestbo, Jørgen

AU - Müller, Veronika

AU - Kunos, Laszlo

AU - Bikov, Andras

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Obstructive sleep apnea is associated with an increased risk of hypertension, diabetes and dyslipidaemia. Both obstructive sleep apnea and its comorbidities are at least partly heritable, suggesting a common genetic background. Our aim was to analyse the heritability of the relationship between obstructive sleep apnea and its comorbidities using a twin study. Forty-seven monozygotic and 22 dizygotic adult twin pairs recruited from the Hungarian Twin Registry (mean age 51 ± 15 years) attended an overnight diagnostic sleep study. A medical history was taken, blood pressure was measured, and blood samples were taken for fasting glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and lipoprotein (a). To evaluate the heritability of obstructive sleep apnea and its comorbidities bivariate analysis was performed with an adjustment for age, gender, body mass index (BMI) and smoking after false discovery rate correction and following exclusion of patients on lipid-lowering and antidiabetic medications. There was a significant correlation between indices of obstructive sleep apnea severity, such as the apnea–hypopnea index, oxygen desaturation index and percentage of sleep time spent with oxygen saturation below 90%, as well as blood pressure, serum triglyceride, lipoprotein (a) and glucose levels (all p <.05). The bivariate analysis revealed a common genetic background for the correlations between serum triglyceride and the oxygen desaturation index (r =.63, p =.03), as well as percentage of sleep time spent with oxygen saturation below 90% (r =.58, p =.03). None of the other correlations were significantly genetically or environmentally determined. This twin study demonstrates that the co-occurrence of obstructive sleep apnea with hypertriglyceridaemia has a genetic influence and heritable factors play an important role in the pathogenesis of dyslipidaemia in obstructive sleep apnea.

AB - Obstructive sleep apnea is associated with an increased risk of hypertension, diabetes and dyslipidaemia. Both obstructive sleep apnea and its comorbidities are at least partly heritable, suggesting a common genetic background. Our aim was to analyse the heritability of the relationship between obstructive sleep apnea and its comorbidities using a twin study. Forty-seven monozygotic and 22 dizygotic adult twin pairs recruited from the Hungarian Twin Registry (mean age 51 ± 15 years) attended an overnight diagnostic sleep study. A medical history was taken, blood pressure was measured, and blood samples were taken for fasting glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and lipoprotein (a). To evaluate the heritability of obstructive sleep apnea and its comorbidities bivariate analysis was performed with an adjustment for age, gender, body mass index (BMI) and smoking after false discovery rate correction and following exclusion of patients on lipid-lowering and antidiabetic medications. There was a significant correlation between indices of obstructive sleep apnea severity, such as the apnea–hypopnea index, oxygen desaturation index and percentage of sleep time spent with oxygen saturation below 90%, as well as blood pressure, serum triglyceride, lipoprotein (a) and glucose levels (all p <.05). The bivariate analysis revealed a common genetic background for the correlations between serum triglyceride and the oxygen desaturation index (r =.63, p =.03), as well as percentage of sleep time spent with oxygen saturation below 90% (r =.58, p =.03). None of the other correlations were significantly genetically or environmentally determined. This twin study demonstrates that the co-occurrence of obstructive sleep apnea with hypertriglyceridaemia has a genetic influence and heritable factors play an important role in the pathogenesis of dyslipidaemia in obstructive sleep apnea.

KW - diabetes mellitus

KW - genetics

KW - lipids

KW - OSAHS

KW - sleep disordered breathing

KW - triacylglycerol

U2 - 10.1111/jsr.12979

DO - 10.1111/jsr.12979

M3 - Journal article

C2 - 31908118

AN - SCOPUS:85078591884

SN - 0962-1105

VL - 29

JO - Journal of Sleep Research

JF - Journal of Sleep Research

IS - 4

M1 - e12979

ER -

Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study

Abstract

Funding

Keywords

Documents & Links

SDU Link

Fingerprint

Cite this