Nucleotide sequence of the CytR regulatory gene of E. coli K-12

P Valentin-Hansen; J E Larsen; P Højrup; S A Short; C S Barbier

doi:10.1093/nar/14.5.2215

Nucleotide sequence of the CytR regulatory gene of E. coli K-12

P Valentin-Hansen, J E Larsen, P Højrup, S A Short, C S Barbier

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We have determined the nucleotide sequence of the cytR gene, which codes for the Cyt repressor (CytR). The coding region consists of 1023 or 1029 bp. The subunits of CytR are thus predicted to consist of 341 or 343 residues. It is shown that the N-terminal segment of the polypeptide is structurally similar to the DNA-binding region of known DNA-binding proteins. In addition, there exists an exceptionally high amino acid sequence homology between CytR and the Gal repressor, indicating a common origin of evolution.

Original language	English
Journal	Nucleic Acids Research
Volume	14
Issue number	5
Pages (from-to)	2215-28
Number of pages	14
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/14.5.2215
Publication status	Published - 11. Mar 1986

Keywords

Amino Acid Sequence
Bacterial Proteins/genetics
Base Sequence
Cloning, Molecular
Codon
DNA-Binding Proteins/genetics
Escherichia coli/genetics
Escherichia coli Proteins
Promoter Regions, Genetic
Receptors, Cyclic AMP/metabolism
Repressor Proteins/genetics
Transcription Factors/genetics

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10.1093/nar/14.5.2215

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title = "Nucleotide sequence of the CytR regulatory gene of E. coli K-12",

abstract = "We have determined the nucleotide sequence of the cytR gene, which codes for the Cyt repressor (CytR). The coding region consists of 1023 or 1029 bp. The subunits of CytR are thus predicted to consist of 341 or 343 residues. It is shown that the N-terminal segment of the polypeptide is structurally similar to the DNA-binding region of known DNA-binding proteins. In addition, there exists an exceptionally high amino acid sequence homology between CytR and the Gal repressor, indicating a common origin of evolution.",

keywords = "Amino Acid Sequence, Bacterial Proteins/genetics, Base Sequence, Cloning, Molecular, Codon, DNA-Binding Proteins/genetics, Escherichia coli/genetics, Escherichia coli Proteins, Promoter Regions, Genetic, Receptors, Cyclic AMP/metabolism, Repressor Proteins/genetics, Transcription Factors/genetics",

author = "P Valentin-Hansen and Larsen, {J E} and P H{\o}jrup and Short, {S A} and Barbier, {C S}",

year = "1986",

month = mar,

day = "11",

doi = "10.1093/nar/14.5.2215",

language = "English",

volume = "14",

pages = "2215--28",

journal = "Nucleic Acids Research",

issn = "0305-1048",

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number = "5",

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TY - JOUR

T1 - Nucleotide sequence of the CytR regulatory gene of E. coli K-12

AU - Valentin-Hansen, P

AU - Larsen, J E

AU - Højrup, P

AU - Short, S A

AU - Barbier, C S

PY - 1986/3/11

Y1 - 1986/3/11

N2 - We have determined the nucleotide sequence of the cytR gene, which codes for the Cyt repressor (CytR). The coding region consists of 1023 or 1029 bp. The subunits of CytR are thus predicted to consist of 341 or 343 residues. It is shown that the N-terminal segment of the polypeptide is structurally similar to the DNA-binding region of known DNA-binding proteins. In addition, there exists an exceptionally high amino acid sequence homology between CytR and the Gal repressor, indicating a common origin of evolution.

AB - We have determined the nucleotide sequence of the cytR gene, which codes for the Cyt repressor (CytR). The coding region consists of 1023 or 1029 bp. The subunits of CytR are thus predicted to consist of 341 or 343 residues. It is shown that the N-terminal segment of the polypeptide is structurally similar to the DNA-binding region of known DNA-binding proteins. In addition, there exists an exceptionally high amino acid sequence homology between CytR and the Gal repressor, indicating a common origin of evolution.

KW - Amino Acid Sequence

KW - Bacterial Proteins/genetics

KW - Base Sequence

KW - Cloning, Molecular

KW - Codon

KW - DNA-Binding Proteins/genetics

KW - Escherichia coli/genetics

KW - Escherichia coli Proteins

KW - Promoter Regions, Genetic

KW - Receptors, Cyclic AMP/metabolism

KW - Repressor Proteins/genetics

KW - Transcription Factors/genetics

U2 - 10.1093/nar/14.5.2215

DO - 10.1093/nar/14.5.2215

M3 - Journal article

C2 - 3515317

SN - 0305-1048

VL - 14

SP - 2215

EP - 2228

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 5

ER -

Nucleotide sequence of the CytR regulatory gene of E. coli K-12

Abstract

Keywords

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