NT-proBNP is associated with fibulin-1 in Africans: the SAfrEIC study

R Kruger; R Schutte; H W Huisman; W S Argraves; Lars Melholt Rasmussen; M H Olsen; A E Schutte

doi:10.1016/j.atherosclerosis.2012.01.045

NT-proBNP is associated with fibulin-1 in Africans: the SAfrEIC study

R Kruger, R Schutte, H W Huisman, W S Argraves, Lars Melholt Rasmussen, M H Olsen, A E Schutte

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is involved in the regulation of volume load and secreted when systemic cardiac overload occurs. Fibulin-1 on the other hand is a component of many extracellular matrix proteins including those present in atherosclerotic lesions, expressed in elastin-containing fibres of blood vessels, and also in the heart. Due to an alarming prevalence of hypertensive heart disease in black South Africans, we investigated the associations of NT-proBNP with fibulin-1 and markers of arterial stiffness in Africans and Caucasians.

Original language	English
Journal	Atherosclerosis
Volume	222
Issue number	1
Pages (from-to)	216-21
Number of pages	6
ISSN	0021-9150
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.01.045
Publication status	Published - 2012

Keywords

Adult
African Continental Ancestry Group
Aged
Blood Flow Velocity
Calcium-Binding Proteins
Cross-Sectional Studies
European Continental Ancestry Group
Female
Humans
Male
Middle Aged
Natriuretic Peptide, Brain
Peptide Fragments
Pulsatile Flow
South Africa
Vascular Stiffness

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10.1016/j.atherosclerosis.2012.01.045

Cite this

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title = "NT-proBNP is associated with fibulin-1 in Africans: the SAfrEIC study",

abstract = "The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is involved in the regulation of volume load and secreted when systemic cardiac overload occurs. Fibulin-1 on the other hand is a component of many extracellular matrix proteins including those present in atherosclerotic lesions, expressed in elastin-containing fibres of blood vessels, and also in the heart. Due to an alarming prevalence of hypertensive heart disease in black South Africans, we investigated the associations of NT-proBNP with fibulin-1 and markers of arterial stiffness in Africans and Caucasians.",

keywords = "Adult, African Continental Ancestry Group, Aged, Blood Flow Velocity, Calcium-Binding Proteins, Cross-Sectional Studies, European Continental Ancestry Group, Female, Humans, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Pulsatile Flow, South Africa, Vascular Stiffness",

author = "R Kruger and R Schutte and Huisman, {H W} and Argraves, {W S} and Rasmussen, {Lars Melholt} and Olsen, {M H} and Schutte, {A E}",

year = "2012",

doi = "10.1016/j.atherosclerosis.2012.01.045",

language = "English",

volume = "222",

pages = "216--21",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - NT-proBNP is associated with fibulin-1 in Africans

T2 - the SAfrEIC study

AU - Kruger, R

AU - Schutte, R

AU - Huisman, H W

AU - Argraves, W S

AU - Rasmussen, Lars Melholt

AU - Olsen, M H

AU - Schutte, A E

PY - 2012

Y1 - 2012

N2 - The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is involved in the regulation of volume load and secreted when systemic cardiac overload occurs. Fibulin-1 on the other hand is a component of many extracellular matrix proteins including those present in atherosclerotic lesions, expressed in elastin-containing fibres of blood vessels, and also in the heart. Due to an alarming prevalence of hypertensive heart disease in black South Africans, we investigated the associations of NT-proBNP with fibulin-1 and markers of arterial stiffness in Africans and Caucasians.

AB - The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is involved in the regulation of volume load and secreted when systemic cardiac overload occurs. Fibulin-1 on the other hand is a component of many extracellular matrix proteins including those present in atherosclerotic lesions, expressed in elastin-containing fibres of blood vessels, and also in the heart. Due to an alarming prevalence of hypertensive heart disease in black South Africans, we investigated the associations of NT-proBNP with fibulin-1 and markers of arterial stiffness in Africans and Caucasians.

KW - Adult

KW - African Continental Ancestry Group

KW - Aged

KW - Blood Flow Velocity

KW - Calcium-Binding Proteins

KW - Cross-Sectional Studies

KW - European Continental Ancestry Group

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain

KW - Peptide Fragments

KW - Pulsatile Flow

KW - South Africa

KW - Vascular Stiffness

U2 - 10.1016/j.atherosclerosis.2012.01.045

DO - 10.1016/j.atherosclerosis.2012.01.045

M3 - Journal article

C2 - 22349089

SN - 0021-9150

VL - 222

SP - 216

EP - 221

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

NT-proBNP is associated with fibulin-1 in Africans: the SAfrEIC study

Abstract

Keywords

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