NT-proBNP is associated with fibulin-1 in Africans: the SAfrEIC study

R Kruger, R Schutte, H W Huisman, W S Argraves, Lars Melholt Rasmussen, M H Olsen, A E Schutte

Research output: Contribution to journalJournal articleResearchpeer-review


The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is involved in the regulation of volume load and secreted when systemic cardiac overload occurs. Fibulin-1 on the other hand is a component of many extracellular matrix proteins including those present in atherosclerotic lesions, expressed in elastin-containing fibres of blood vessels, and also in the heart. Due to an alarming prevalence of hypertensive heart disease in black South Africans, we investigated the associations of NT-proBNP with fibulin-1 and markers of arterial stiffness in Africans and Caucasians.
Original languageEnglish
Issue number1
Pages (from-to)216-21
Number of pages6
Publication statusPublished - 2012


  • Adult
  • African Continental Ancestry Group
  • Aged
  • Blood Flow Velocity
  • Calcium-Binding Proteins
  • Cross-Sectional Studies
  • European Continental Ancestry Group
  • Female
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Pulsatile Flow
  • South Africa
  • Vascular Stiffness


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