NT-proBNP and potential vascular calcification in Black and Caucasian African men: the SAfrEIC study

Ruan Kruger; Rudolph Schutte; Hugo W Huisman; Michael H Olsen; Aletta E Schutte

NT-proBNP and potential vascular calcification in Black and Caucasian African men: the SAfrEIC study

Ruan Kruger, Rudolph Schutte, Hugo W Huisman, Michael H Olsen, Aletta E Schutte

KI, OUH, Research unit of Endocrinology (Odense)

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is a reliable marker of cardiac strain. In hypertensive heart disease, NT-proBNP levels increase and may lose its protective function. Simultaneously, the vasculature is also subject to hemodynamic stress, resulting in vascular matrix remodeling and stiffening which contribute to further cardiac alterations. Alkaline phosphatase (ALP) is a marker of osteoblast activity and is involved in vascular calcification. We explored the link between NT-proBNP and ALP in Black and Caucasian African men.

Original language	English
Journal	Ethnicity & Disease
Volume	22
Issue number	4
Pages (from-to)	398-403
Number of pages	6
ISSN	1049-510X
Publication status	Published - 2012

Keywords

Adult
African Continental Ancestry Group
Alkaline Phosphatase
Biological Markers
Blood Vessels
Calcinosis
Cross-Sectional Studies
European Continental Ancestry Group
Humans
Male
Middle Aged
Natriuretic Peptide, Brain
Peptide Fragments
South Africa
Vascular Stiffness

Cite this

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title = "NT-proBNP and potential vascular calcification in Black and Caucasian African men: the SAfrEIC study",

abstract = "The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is a reliable marker of cardiac strain. In hypertensive heart disease, NT-proBNP levels increase and may lose its protective function. Simultaneously, the vasculature is also subject to hemodynamic stress, resulting in vascular matrix remodeling and stiffening which contribute to further cardiac alterations. Alkaline phosphatase (ALP) is a marker of osteoblast activity and is involved in vascular calcification. We explored the link between NT-proBNP and ALP in Black and Caucasian African men.",

keywords = "Adult, African Continental Ancestry Group, Alkaline Phosphatase, Biological Markers, Blood Vessels, Calcinosis, Cross-Sectional Studies, European Continental Ancestry Group, Humans, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, South Africa, Vascular Stiffness",

author = "Ruan Kruger and Rudolph Schutte and Huisman, {Hugo W} and Olsen, {Michael H} and Schutte, {Aletta E}",

year = "2012",

language = "English",

volume = "22",

pages = "398--403",

journal = "Ethnicity & Disease",

issn = "1049-510X",

publisher = "International Society on Hypertension in Blacks",

number = "4",

}

TY - JOUR

T1 - NT-proBNP and potential vascular calcification in Black and Caucasian African men

T2 - the SAfrEIC study

AU - Kruger, Ruan

AU - Schutte, Rudolph

AU - Huisman, Hugo W

AU - Olsen, Michael H

AU - Schutte, Aletta E

PY - 2012

Y1 - 2012

N2 - The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is a reliable marker of cardiac strain. In hypertensive heart disease, NT-proBNP levels increase and may lose its protective function. Simultaneously, the vasculature is also subject to hemodynamic stress, resulting in vascular matrix remodeling and stiffening which contribute to further cardiac alterations. Alkaline phosphatase (ALP) is a marker of osteoblast activity and is involved in vascular calcification. We explored the link between NT-proBNP and ALP in Black and Caucasian African men.

AB - The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is a reliable marker of cardiac strain. In hypertensive heart disease, NT-proBNP levels increase and may lose its protective function. Simultaneously, the vasculature is also subject to hemodynamic stress, resulting in vascular matrix remodeling and stiffening which contribute to further cardiac alterations. Alkaline phosphatase (ALP) is a marker of osteoblast activity and is involved in vascular calcification. We explored the link between NT-proBNP and ALP in Black and Caucasian African men.

KW - Adult

KW - African Continental Ancestry Group

KW - Alkaline Phosphatase

KW - Biological Markers

KW - Blood Vessels

KW - Calcinosis

KW - Cross-Sectional Studies

KW - European Continental Ancestry Group

KW - Humans

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain

KW - Peptide Fragments

KW - South Africa

KW - Vascular Stiffness

M3 - Journal article

C2 - 23140068

SN - 1049-510X

VL - 22

SP - 398

EP - 403

JO - Ethnicity & Disease

JF - Ethnicity & Disease

IS - 4

ER -

NT-proBNP and potential vascular calcification in Black and Caucasian African men: the SAfrEIC study

Abstract

Keywords

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