Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity

Magnus S Agren; Thomas Levin Andersen; Line Andersen; Christine Bruun Schiødt; Vikas Surve; Troels T Andreassen; Juha Risteli; Lennart E Franzén; Jean-Marie Delaissé; Anne-Marie Heegaard; Lars N Jorgensen

doi:10.1007/s00384-010-1106-3

Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity

Magnus S Agren, Thomas Levin Andersen, Line Andersen, Christine Bruun Schiødt, Vikas Surve, Troels T Andreassen, Juha Risteli, Lennart E Franzén, Jean-Marie Delaissé, Anne-Marie Heegaard, Lars N Jorgensen

The Faculty of Health Sciences

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

BACKGROUND: Increased matrix metalloproteinase (MMP) activity has been implicated in the pathogenesis of colorectal anastomotic leakage. Tumor necrosis factor-α (TNF-α) induces MMPs and may influence anastomosis repair. METHODS: We assessed the efficacies of the nonselective hydroxamate MMP inhibitor GM6001, the selective hydroxamate MMP inhibitor AG3340 and a TNF-α antagonist with respect to anastomotic breaking strength of left-sided colon anastomoses in male Sprague-Dawley rats. RESULTS: Systemic GM6001 treatment effectively blocked MMP activity and maintained the initial breaking strength day 0 of the anastomoses when administered subcutaneously as daily depositions (100 mg/kg) or continuously (10 mg/kg/day). In contrast, the anastomotic biomechanic strength was lowered by 55% (p

Original language	English
Journal	International Journal of Colorectal Disease
Volume	26
Issue number	3
Pages (from-to)	329-337
ISSN	1432-1262
DOIs	https://doi.org/10.1007/s00384-010-1106-3
Publication status	Published - 2011

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10.1007/s00384-010-1106-3

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Agren, M. S., Levin Andersen, T., Andersen, L., Schiødt, C. B., Surve, V., Andreassen, T. T., Risteli, J., Franzén, L. E., Delaissé, J.-M., Heegaard, A.-M., & Jorgensen, L. N. (2011). Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity. International Journal of Colorectal Disease, 26(3), 329-337. https://doi.org/10.1007/s00384-010-1106-3

@article{1831de6ad78f4ffa9347a540636893bc,

title = "Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity",

abstract = "BACKGROUND: Increased matrix metalloproteinase (MMP) activity has been implicated in the pathogenesis of colorectal anastomotic leakage. Tumor necrosis factor-α (TNF-α) induces MMPs and may influence anastomosis repair. METHODS: We assessed the efficacies of the nonselective hydroxamate MMP inhibitor GM6001, the selective hydroxamate MMP inhibitor AG3340 and a TNF-α antagonist with respect to anastomotic breaking strength of left-sided colon anastomoses in male Sprague-Dawley rats. RESULTS: Systemic GM6001 treatment effectively blocked MMP activity and maintained the initial breaking strength day 0 of the anastomoses when administered subcutaneously as daily depositions (100 mg/kg) or continuously (10 mg/kg/day). In contrast, the anastomotic biomechanic strength was lowered by 55% (p ",

author = "Agren, {Magnus S} and {Levin Andersen}, Thomas and Line Andersen and Schi{\o}dt, {Christine Bruun} and Vikas Surve and Andreassen, {Troels T} and Juha Risteli and Franz{\'e}n, {Lennart E} and Jean-Marie Delaiss{\'e} and Anne-Marie Heegaard and Jorgensen, {Lars N}",

year = "2011",

doi = "10.1007/s00384-010-1106-3",

language = "English",

volume = "26",

pages = "329--337",

journal = "International Journal of Colorectal Disease",

issn = "1432-1262",

publisher = "Springer",

number = "3",

}

Agren, MS, Levin Andersen, T, Andersen, L, Schiødt, CB, Surve, V, Andreassen, TT, Risteli, J, Franzén, LE, Delaissé, J-M, Heegaard, A-M & Jorgensen, LN 2011, 'Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity', International Journal of Colorectal Disease, vol. 26, no. 3, pp. 329-337. https://doi.org/10.1007/s00384-010-1106-3

Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity. / Agren, Magnus S; Levin Andersen, Thomas; Andersen, Line et al.
In: International Journal of Colorectal Disease, Vol. 26, No. 3, 2011, p. 329-337.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity

AU - Agren, Magnus S

AU - Levin Andersen, Thomas

AU - Andersen, Line

AU - Schiødt, Christine Bruun

AU - Surve, Vikas

AU - Andreassen, Troels T

AU - Risteli, Juha

AU - Franzén, Lennart E

AU - Delaissé, Jean-Marie

AU - Heegaard, Anne-Marie

AU - Jorgensen, Lars N

PY - 2011

Y1 - 2011

N2 - BACKGROUND: Increased matrix metalloproteinase (MMP) activity has been implicated in the pathogenesis of colorectal anastomotic leakage. Tumor necrosis factor-α (TNF-α) induces MMPs and may influence anastomosis repair. METHODS: We assessed the efficacies of the nonselective hydroxamate MMP inhibitor GM6001, the selective hydroxamate MMP inhibitor AG3340 and a TNF-α antagonist with respect to anastomotic breaking strength of left-sided colon anastomoses in male Sprague-Dawley rats. RESULTS: Systemic GM6001 treatment effectively blocked MMP activity and maintained the initial breaking strength day 0 of the anastomoses when administered subcutaneously as daily depositions (100 mg/kg) or continuously (10 mg/kg/day). In contrast, the anastomotic biomechanic strength was lowered by 55% (p

AB - BACKGROUND: Increased matrix metalloproteinase (MMP) activity has been implicated in the pathogenesis of colorectal anastomotic leakage. Tumor necrosis factor-α (TNF-α) induces MMPs and may influence anastomosis repair. METHODS: We assessed the efficacies of the nonselective hydroxamate MMP inhibitor GM6001, the selective hydroxamate MMP inhibitor AG3340 and a TNF-α antagonist with respect to anastomotic breaking strength of left-sided colon anastomoses in male Sprague-Dawley rats. RESULTS: Systemic GM6001 treatment effectively blocked MMP activity and maintained the initial breaking strength day 0 of the anastomoses when administered subcutaneously as daily depositions (100 mg/kg) or continuously (10 mg/kg/day). In contrast, the anastomotic biomechanic strength was lowered by 55% (p

U2 - 10.1007/s00384-010-1106-3

DO - 10.1007/s00384-010-1106-3

M3 - Journal article

C2 - 21193914

SN - 1432-1262

VL - 26

SP - 329

EP - 337

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

IS - 3

ER -

Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity

Abstract

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