Non-Equilibrium Thermodynamics of Self-Replicating Protocells

Harold Fellermann, Bernat Corominas-Murtra, Per Lyngs Hansen, John Hjort Ipsen, Ricard Solé, Steen Rasmussen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We provide a non-equilibrium thermodynamic description of the life-cycle of a droplet based, chemically feasible, system of protocells. By coupling the protocells metabolic kinetics with its thermodynamics, we demonstrate how the system can be driven out of equilibrium to ensure protocell growth and replication. This coupling allows us to derive the equations of evolution and to
rigorously demonstrate how growth and replication life-cycle can be understood as a non-equilibrium thermodynamic cycle. The process does not appeal to genetic information or inheritance, and is based only on non-equilibrium physics considerations. Our non-equilibrium thermodynamic description
of simple, yet realistic, processes of protocell growth and replication, represents an advance in our physical understanding of a central biological phenomenon both in connection to the origin of life and for modern biology.
Original languageEnglish
JournalScientific Reports
Number of pages13
ISSN2045-2322
Publication statusAccepted/In press - 2018

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nonequilibrium thermodynamics
thermodynamic cycles
cycles
biology
thermodynamics
physics
kinetics

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Fellermann, H., Corominas-Murtra, B., Hansen, P. L., Ipsen, J. H., Solé, R., & Rasmussen, S. (Accepted/In press). Non-Equilibrium Thermodynamics of Self-Replicating Protocells. Scientific Reports.
Fellermann, Harold ; Corominas-Murtra, Bernat ; Hansen, Per Lyngs ; Ipsen, John Hjort ; Solé, Ricard ; Rasmussen, Steen . / Non-Equilibrium Thermodynamics of Self-Replicating Protocells. In: Scientific Reports. 2018.
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Non-Equilibrium Thermodynamics of Self-Replicating Protocells. / Fellermann, Harold; Corominas-Murtra, Bernat; Hansen, Per Lyngs; Ipsen, John Hjort; Solé, Ricard; Rasmussen, Steen .

In: Scientific Reports, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

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AU - Fellermann, Harold

AU - Corominas-Murtra, Bernat

AU - Hansen, Per Lyngs

AU - Ipsen, John Hjort

AU - Solé, Ricard

AU - Rasmussen, Steen

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AB - We provide a non-equilibrium thermodynamic description of the life-cycle of a droplet based, chemically feasible, system of protocells. By coupling the protocells metabolic kinetics with its thermodynamics, we demonstrate how the system can be driven out of equilibrium to ensure protocell growth and replication. This coupling allows us to derive the equations of evolution and torigorously demonstrate how growth and replication life-cycle can be understood as a non-equilibrium thermodynamic cycle. The process does not appeal to genetic information or inheritance, and is based only on non-equilibrium physics considerations. Our non-equilibrium thermodynamic descriptionof simple, yet realistic, processes of protocell growth and replication, represents an advance in our physical understanding of a central biological phenomenon both in connection to the origin of life and for modern biology.

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JF - Scientific Reports

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