No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Experimental evidence suggests that monoamine oxidase B (MAO-B) and muscarinic cholinergic receptors (mAChRs) are involved in the pathogenesis of neurotoxicity caused by methylmercury and polychlorinated biphenyls (PCBs). Blood samples from 7-year-old exposed children were analyzed for platelet MAO-B and lymphocyte mAChRs as potential markers of exposure to these neurotoxicants. The blood neurotoxicity biomarkers were compared with prenatal and current exposures and with neuropsychological test results. Both biomarkers showed homogeneous distributions within this cohort (mAChR, range 0.04-36.78 fmol/million cells; MAO-B, 0.95-14.95 nmol mg(-1) protein h(-1)). No correlation was found between the two biomarkers and either blood neurotoxicant concentrations or clinical findings. MAO-B and mAChR sensitivity may not be sufficiently high to assess early, subclinical responses to low/moderate methylmercury and/or PCB exposure, whereas these markers are significantly altered in sustained exposure scenarios, as shown by clinical studies in drug addicts or patients treated with psychopharmacological agents.
Original languageEnglish
JournalBiomarkers
Volume14
Issue number2
Pages (from-to)67-76
Number of pages9
ISSN1354-750X
DOIs
Publication statusPublished - 1. Mar 2009

Keywords

  • Biological Markers
  • Blood Platelets
  • Child
  • Cohort Studies
  • Female
  • Humans
  • Lymphocytes
  • Male
  • Methylmercury Compounds
  • Monoamine Oxidase
  • Neuropsychological Tests
  • Polychlorinated Biphenyls
  • Pregnancy
  • Prenatal Exposure Delayed Effects

Fingerprint Dive into the research topics of 'No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls'. Together they form a unique fingerprint.

  • Cite this