New and Emerging Systemic Treatments for Atopic Dermatitis

Megan Newsom*, Arjun M. Bashyam, Esther A. Balogh, Steven R. Feldman, Lindsay C. Strowd

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Atopic dermatitis (AD) is a prevalent inflammatory skin condition that, depending on its severity, can cause enormous morbidity. Corticosteroids and systemic immunosuppression, traditionally standard of care for difficult-to-treat disease, have many undesirable side effects. The desire for targeted treatments along with an improved understanding of the pathophysiology of AD has spurred the development of novel treatments. In this article, we review promising new treatments and discuss how their targets—IL-13, IL-31, OX40 (CD134), and the Janus kinase family of proteins—participate in the pathogenesis of AD. We review the published phase II and III data for dupilumab, tralokinumab, lebrikizumab, nemolizumab, anti-OX40 antibody, baricitinib, abrocitinib, and upadacitinib. The introduction of new agents may offer new options, but it remains to be seen how narrow-acting agents, like single interleukin inhibitors, will compare in safety and efficacy to broad-acting agents such as JAK inhibitors.

Original languageEnglish
Issue number11
Pages (from-to)1041-1052
Publication statusPublished - Jul 2020

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