Nasal symptoms in patients with NSAID hypersensitivity

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Abstract

Background: Approximately 1 to 2% of the general population suffers from nonsteroidal anti-inflammatory drugs (NSAID)hypersensitivity. NSAID hypersensitivity is closely associated with concomitant respiratory disease. Exact knowledge of sino-nasalsymptoms among patients with NSAID hypersensitivity is important as patients with NSAID hypersensitivity are at risk of havingunderdiagnosed, undertreated chronic rhinosinusitis with affected QoL. The aim of this study was to estimate the prevalence ofchronic rhinosinusitis in patients with NSAID hypersensitivity and to evaluate QoL and the need of ENT intervention.Methodology: Patients with confirmed NSAID hypersensitivity at the Allergy Centre were referred to the Department of Otorhinolaryngology for evaluation by an ENT specialist. All patients completed the Sino Nasal Outcome test 22 (QoL) and underwentnasal endoscopy and smell test.Results: A total of 46 patients with NSAID hypersensitivity participated in ENT evaluation. Chronic rhinosinusitis was diagnosed in19 patients. The mean Sino Nasal Outcome test 22 score was 39 in patients with chronic rhinosinusitis and 17 in patients withoutchronic rhinosinusitis. The sense of smell was decreased in patients with chronic rhinosinusitis. Nasal steroid was indicated in 22patients. Seven patients had former sinus surgery and 10 patients underwent new sinus or nasal surgery.Conclusion: With a prevalence of 41% more than one third of patients with NSAID hypersensitivity have chronic rhinosinusitiswith decreased QoL. In patients with sino-nasal problems medical and surgical advice and treatment is important. It is recommended that patients with NSAID hypersensitivity are screened for sino-nasal symptoms and referred for ENT evaluation.
Original languageEnglish
JournalRhinology Online
Volume2
Pages (from-to)91-96
Number of pages6
DOIs
Publication statusPublished - 12. Jun 2019

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Drug Hypersensitivity
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Smell

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@article{98d1b386cf0d4076b9221608fdae1237,
title = "Nasal symptoms in patients with NSAID hypersensitivity",
abstract = "Background: Approximately 1 to 2{\%} of the general population suffers from nonsteroidal anti-inflammatory drugs (NSAID)hypersensitivity. NSAID hypersensitivity is closely associated with concomitant respiratory disease. Exact knowledge of sino-nasalsymptoms among patients with NSAID hypersensitivity is important as patients with NSAID hypersensitivity are at risk of havingunderdiagnosed, undertreated chronic rhinosinusitis with affected QoL. The aim of this study was to estimate the prevalence ofchronic rhinosinusitis in patients with NSAID hypersensitivity and to evaluate QoL and the need of ENT intervention.Methodology: Patients with confirmed NSAID hypersensitivity at the Allergy Centre were referred to the Department of Otorhinolaryngology for evaluation by an ENT specialist. All patients completed the Sino Nasal Outcome test 22 (QoL) and underwentnasal endoscopy and smell test.Results: A total of 46 patients with NSAID hypersensitivity participated in ENT evaluation. Chronic rhinosinusitis was diagnosed in19 patients. The mean Sino Nasal Outcome test 22 score was 39 in patients with chronic rhinosinusitis and 17 in patients withoutchronic rhinosinusitis. The sense of smell was decreased in patients with chronic rhinosinusitis. Nasal steroid was indicated in 22patients. Seven patients had former sinus surgery and 10 patients underwent new sinus or nasal surgery.Conclusion: With a prevalence of 41{\%} more than one third of patients with NSAID hypersensitivity have chronic rhinosinusitiswith decreased QoL. In patients with sino-nasal problems medical and surgical advice and treatment is important. It is recommended that patients with NSAID hypersensitivity are screened for sino-nasal symptoms and referred for ENT evaluation.",
author = "Bibi Lange and {Gotthard M{\o}rtz}, Charlotte and Carsten Bindslev-Jensen and Kjeldsen, {A. D.}",
year = "2019",
month = "6",
day = "12",
doi = "10.4193/RHINOL/19.009",
language = "English",
volume = "2",
pages = "91--96",
journal = "Rhinology Online",

}

Nasal symptoms in patients with NSAID hypersensitivity. / Lange, Bibi; Gotthard Mørtz, Charlotte; Bindslev-Jensen, Carsten; Kjeldsen, A. D. .

In: Rhinology Online, Vol. 2, 12.06.2019, p. 91-96.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Nasal symptoms in patients with NSAID hypersensitivity

AU - Lange, Bibi

AU - Gotthard Mørtz, Charlotte

AU - Bindslev-Jensen, Carsten

AU - Kjeldsen, A. D.

PY - 2019/6/12

Y1 - 2019/6/12

N2 - Background: Approximately 1 to 2% of the general population suffers from nonsteroidal anti-inflammatory drugs (NSAID)hypersensitivity. NSAID hypersensitivity is closely associated with concomitant respiratory disease. Exact knowledge of sino-nasalsymptoms among patients with NSAID hypersensitivity is important as patients with NSAID hypersensitivity are at risk of havingunderdiagnosed, undertreated chronic rhinosinusitis with affected QoL. The aim of this study was to estimate the prevalence ofchronic rhinosinusitis in patients with NSAID hypersensitivity and to evaluate QoL and the need of ENT intervention.Methodology: Patients with confirmed NSAID hypersensitivity at the Allergy Centre were referred to the Department of Otorhinolaryngology for evaluation by an ENT specialist. All patients completed the Sino Nasal Outcome test 22 (QoL) and underwentnasal endoscopy and smell test.Results: A total of 46 patients with NSAID hypersensitivity participated in ENT evaluation. Chronic rhinosinusitis was diagnosed in19 patients. The mean Sino Nasal Outcome test 22 score was 39 in patients with chronic rhinosinusitis and 17 in patients withoutchronic rhinosinusitis. The sense of smell was decreased in patients with chronic rhinosinusitis. Nasal steroid was indicated in 22patients. Seven patients had former sinus surgery and 10 patients underwent new sinus or nasal surgery.Conclusion: With a prevalence of 41% more than one third of patients with NSAID hypersensitivity have chronic rhinosinusitiswith decreased QoL. In patients with sino-nasal problems medical and surgical advice and treatment is important. It is recommended that patients with NSAID hypersensitivity are screened for sino-nasal symptoms and referred for ENT evaluation.

AB - Background: Approximately 1 to 2% of the general population suffers from nonsteroidal anti-inflammatory drugs (NSAID)hypersensitivity. NSAID hypersensitivity is closely associated with concomitant respiratory disease. Exact knowledge of sino-nasalsymptoms among patients with NSAID hypersensitivity is important as patients with NSAID hypersensitivity are at risk of havingunderdiagnosed, undertreated chronic rhinosinusitis with affected QoL. The aim of this study was to estimate the prevalence ofchronic rhinosinusitis in patients with NSAID hypersensitivity and to evaluate QoL and the need of ENT intervention.Methodology: Patients with confirmed NSAID hypersensitivity at the Allergy Centre were referred to the Department of Otorhinolaryngology for evaluation by an ENT specialist. All patients completed the Sino Nasal Outcome test 22 (QoL) and underwentnasal endoscopy and smell test.Results: A total of 46 patients with NSAID hypersensitivity participated in ENT evaluation. Chronic rhinosinusitis was diagnosed in19 patients. The mean Sino Nasal Outcome test 22 score was 39 in patients with chronic rhinosinusitis and 17 in patients withoutchronic rhinosinusitis. The sense of smell was decreased in patients with chronic rhinosinusitis. Nasal steroid was indicated in 22patients. Seven patients had former sinus surgery and 10 patients underwent new sinus or nasal surgery.Conclusion: With a prevalence of 41% more than one third of patients with NSAID hypersensitivity have chronic rhinosinusitiswith decreased QoL. In patients with sino-nasal problems medical and surgical advice and treatment is important. It is recommended that patients with NSAID hypersensitivity are screened for sino-nasal symptoms and referred for ENT evaluation.

U2 - 10.4193/RHINOL/19.009

DO - 10.4193/RHINOL/19.009

M3 - Journal article

VL - 2

SP - 91

EP - 96

JO - Rhinology Online

JF - Rhinology Online

ER -