Myeloproliferative Neoplasms in Danish Twins

Michael Asger Andersen, Ole Weis Bjerrum, Ajenthen Ranjan, Vibe Skov, Torben A Kruse, Mads Thomassen, Axel Skytthe, Hans Carl Hasselbalch, Kaare Christensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.

METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.

RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).

CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

Original languageEnglish
JournalActa Haematologica
Volume139
Issue number3
Pages (from-to)195-198
ISSN0001-5792
DOIs
Publication statusPublished - 3. May 2018

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Neoplasms
Monozygotic Twins
Registries
Dizygotic Twins
Cell Lineage

Keywords

  • Heredity
  • Myeloproliferative neoplasms
  • Philadelphianegative myeloproliferative neoplasms
  • Registry studies
  • Twins
  • Twins/statistics & numerical data
  • Disease Susceptibility
  • Myeloproliferative Disorders/epidemiology
  • Humans
  • Middle Aged
  • Twins, Dizygotic
  • Male
  • Twins, Monozygotic
  • Denmark/epidemiology
  • Adult
  • Female
  • Registries
  • Aged
  • Population Surveillance

Cite this

Andersen, Michael Asger ; Bjerrum, Ole Weis ; Ranjan, Ajenthen ; Skov, Vibe ; Kruse, Torben A ; Thomassen, Mads ; Skytthe, Axel ; Hasselbalch, Hans Carl ; Christensen, Kaare. / Myeloproliferative Neoplasms in Danish Twins. In: Acta Haematologica. 2018 ; Vol. 139, No. 3. pp. 195-198.
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abstract = "OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0{\%}; p = 0.016).CONCLUSION: An estimated concordance rate of 15{\%} (95{\%} CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.",
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Andersen, MA, Bjerrum, OW, Ranjan, A, Skov, V, Kruse, TA, Thomassen, M, Skytthe, A, Hasselbalch, HC & Christensen, K 2018, 'Myeloproliferative Neoplasms in Danish Twins', Acta Haematologica, vol. 139, no. 3, pp. 195-198. https://doi.org/10.1159/000488384

Myeloproliferative Neoplasms in Danish Twins. / Andersen, Michael Asger; Bjerrum, Ole Weis; Ranjan, Ajenthen; Skov, Vibe; Kruse, Torben A; Thomassen, Mads; Skytthe, Axel; Hasselbalch, Hans Carl; Christensen, Kaare.

In: Acta Haematologica, Vol. 139, No. 3, 03.05.2018, p. 195-198.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Myeloproliferative Neoplasms in Danish Twins

AU - Andersen, Michael Asger

AU - Bjerrum, Ole Weis

AU - Ranjan, Ajenthen

AU - Skov, Vibe

AU - Kruse, Torben A

AU - Thomassen, Mads

AU - Skytthe, Axel

AU - Hasselbalch, Hans Carl

AU - Christensen, Kaare

N1 - © 2018 S. Karger AG, Basel.

PY - 2018/5/3

Y1 - 2018/5/3

N2 - OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

AB - OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

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KW - Registry studies

KW - Twins

KW - Twins/statistics & numerical data

KW - Disease Susceptibility

KW - Myeloproliferative Disorders/epidemiology

KW - Humans

KW - Middle Aged

KW - Twins, Dizygotic

KW - Male

KW - Twins, Monozygotic

KW - Denmark/epidemiology

KW - Adult

KW - Female

KW - Registries

KW - Aged

KW - Population Surveillance

U2 - 10.1159/000488384

DO - 10.1159/000488384

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JO - Acta Haematologica

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Andersen MA, Bjerrum OW, Ranjan A, Skov V, Kruse TA, Thomassen M et al. Myeloproliferative Neoplasms in Danish Twins. Acta Haematologica. 2018 May 3;139(3):195-198. https://doi.org/10.1159/000488384