Myeloma-bone marrow adipocyte axis in tumour survival and treatment response

Abbas Jafari; Heather Fairfield; Thomas L. Andersen; Michaela R. Reagan

doi:10.1038/s41416-021-01371-4

Myeloma-bone marrow adipocyte axis in tumour survival and treatment response

Abbas Jafari^*
, Heather Fairfield
, Thomas L. Andersen
, Michaela R. Reagan

^*Corresponding author for this work

KI, OUH, Research unit of Pathology (Odense)

Research output: Contribution to journal › Comment/debate › Research › peer-review

Abstract

Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfunction and senescence-associated secretory phenotype in BMAds.

Original language	English
Journal	British Journal of Cancer
Volume	125
Issue number	6
Pages (from-to)	775-777
ISSN	0007-0920
DOIs	https://doi.org/10.1038/s41416-021-01371-4
Publication status	Published - Sept 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Cancer Research UK.

Funding

Funding information T.L.A. had received funding from the Region of Southern Denmark (20/14282). M.R.R. had received funding from the American Cancer Society (Research Grant #RSG-19-037-01-LIB), the NIH (U54GM115516, R01AR049069, R37CA245330, and P20GM121301) and the Kane Foundation.

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@article{80358fba0aec4472bcc7010ddeaf0a0f,

title = "Myeloma-bone marrow adipocyte axis in tumour survival and treatment response",

abstract = "Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfunction and senescence-associated secretory phenotype in BMAds.",

author = "Abbas Jafari and Heather Fairfield and Andersen, \{Thomas L.\} and Reagan, \{Michaela R.\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Cancer Research UK.",

year = "2021",

month = sep,

doi = "10.1038/s41416-021-01371-4",

language = "English",

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journal = "British Journal of Cancer",

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T1 - Myeloma-bone marrow adipocyte axis in tumour survival and treatment response

AU - Jafari, Abbas

AU - Fairfield, Heather

AU - Andersen, Thomas L.

AU - Reagan, Michaela R.

PY - 2021/9

Y1 - 2021/9

N2 - Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfunction and senescence-associated secretory phenotype in BMAds.

AB - Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfunction and senescence-associated secretory phenotype in BMAds.

U2 - 10.1038/s41416-021-01371-4

DO - 10.1038/s41416-021-01371-4

M3 - Comment/debate

C2 - 33859343

AN - SCOPUS:85104322403

SN - 0007-0920

VL - 125

SP - 775

EP - 777

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 6

ER -

Myeloma-bone marrow adipocyte axis in tumour survival and treatment response

Abstract

Bibliographical note

Funding

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