Myeloma-bone marrow adipocyte axis in tumour survival and treatment response

Abbas Jafari*, Heather Fairfield, Thomas L. Andersen, Michaela R. Reagan

*Corresponding author for this work

Research output: Contribution to journalComment/debateResearchpeer-review

Abstract

Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfunction and senescence-associated secretory phenotype in BMAds.

Original languageEnglish
JournalBritish Journal of Cancer
Volume125
Issue number6
Pages (from-to)775-777
ISSN0007-0920
DOIs
Publication statusPublished - Sep 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Cancer Research UK.

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