MYC activates transcriptional enhancers to drive cancer progression

Rasmus Siersbæk; Simon Toftholm Jakobsen

doi:10.1038/s41588-024-01677-y

MYC activates transcriptional enhancers to drive cancer progression

Rasmus Siersbæk, Simon Toftholm Jakobsen

Research output: Contribution to journal › Journal article › Communication

Abstract

We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.

Original language	English
Journal	Nature Genetics
Volume	56
Issue number	4
Pages (from-to)	567-568
ISSN	1061-4036
DOIs	https://doi.org/10.1038/s41588-024-01677-y
Publication status	Published - Apr 2024

Keywords

Humans
Cell Line, Tumor
Enhancer Elements, Genetic/genetics
Genes, myc
Neoplasms/genetics
Proto-Oncogene Proteins c-myc/genetics
Regulatory Sequences, Nucleic Acid

Documents & Links

10.1038/s41588-024-01677-y

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Associate professor - Transcriptional Regulation at Single-Cell Resolution (may change)
Siersbæk, R. (Project manager), Jakobsen, S. T. (Postdoc) & Katariya, P. D. (PhD student)
01/04/2022 → 31/03/2027
Project: Private Foundations

Cite this

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title = "MYC activates transcriptional enhancers to drive cancer progression",

abstract = "We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.",

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year = "2024",

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doi = "10.1038/s41588-024-01677-y",

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T1 - MYC activates transcriptional enhancers to drive cancer progression

AU - Siersbæk, Rasmus

AU - Jakobsen, Simon Toftholm

PY - 2024/4

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N2 - We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.

AB - We show that in addition to promoter activation, MYC drives cancer progression by activating transcriptional enhancers via a distinct mechanism. MYC cooperates with several other proteins at these cis-regulatory regions to change the epigenome and promote recruitment of RNA polymerase II and enhancer transcription.

KW - Humans

KW - Cell Line, Tumor

KW - Enhancer Elements, Genetic/genetics

KW - Genes, myc

KW - Neoplasms/genetics

KW - Proto-Oncogene Proteins c-myc/genetics

KW - Regulatory Sequences, Nucleic Acid

U2 - 10.1038/s41588-024-01677-y

DO - 10.1038/s41588-024-01677-y

M3 - Journal article

C2 - 38480925

SN - 1061-4036

VL - 56

SP - 567

EP - 568

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

MYC activates transcriptional enhancers to drive cancer progression

Abstract

Keywords

Documents & Links

SDU Link

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Associate professor - Transcriptional Regulation at Single-Cell Resolution (may change)

Cite this