MRM quantification of chitotriosidase in human plasma: Application Note

Richard Remko Sprenger; Catalin Doneanu; Jim Langridge; Hans Vissers; Hans Aerts

MRM quantification of chitotriosidase in human plasma: Application Note

Richard Remko Sprenger, Catalin Doneanu, Jim Langridge, Hans Vissers, Hans Aerts

Research output: Other contribution › Net publication - Internet publication › Research

Abstract

Alternative LC/MS-based quantification methods have been applied to measure the amounts, concentration, and plasma activity of chitotriosidase for various Gaucher disease patients. LC/MSE and LC/MRM-MS/MS-based quantification methods have both been applied to measure the concentration of plasma proteins in an untargeted and targeted fashion, respectively. The qualitative results of the LC/MSE experiments were used to direct the development of unique, non-interfered MRM transitions for chitotriosidase.

Original language	English
Publication date	2009
Publication status	Published - 2009
Externally published	Yes

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@misc{5e0e77e23a8b44e995d9d17473d733f4,

title = "MRM quantification of chitotriosidase in human plasma: Application Note",

abstract = "Alternative LC/MS-based quantification methods have been applied to measure the amounts, concentration, and plasma activity of chitotriosidase for various Gaucher disease patients. LC/MSE and LC/MRM-MS/MS-based quantification methods have both been applied to measure the concentration of plasma proteins in an untargeted and targeted fashion, respectively. The qualitative results of the LC/MSE experiments were used to direct the development of unique, non-interfered MRM transitions for chitotriosidase.",

author = "Sprenger, {Richard Remko} and Catalin Doneanu and Jim Langridge and Hans Vissers and Hans Aerts",

year = "2009",

language = "English",

type = "Other",

}

TY - ICOMM

T1 - MRM quantification of chitotriosidase in human plasma

T2 - Application Note

AU - Sprenger, Richard Remko

AU - Doneanu, Catalin

AU - Langridge, Jim

AU - Vissers, Hans

AU - Aerts, Hans

PY - 2009

Y1 - 2009

N2 - Alternative LC/MS-based quantification methods have been applied to measure the amounts, concentration, and plasma activity of chitotriosidase for various Gaucher disease patients. LC/MSE and LC/MRM-MS/MS-based quantification methods have both been applied to measure the concentration of plasma proteins in an untargeted and targeted fashion, respectively. The qualitative results of the LC/MSE experiments were used to direct the development of unique, non-interfered MRM transitions for chitotriosidase.

AB - Alternative LC/MS-based quantification methods have been applied to measure the amounts, concentration, and plasma activity of chitotriosidase for various Gaucher disease patients. LC/MSE and LC/MRM-MS/MS-based quantification methods have both been applied to measure the concentration of plasma proteins in an untargeted and targeted fashion, respectively. The qualitative results of the LC/MSE experiments were used to direct the development of unique, non-interfered MRM transitions for chitotriosidase.

M3 - Net publication - Internet publication

ER -

MRM quantification of chitotriosidase in human plasma: Application Note

Abstract

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