Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension

Sabine Klein, Robert Schierwagen, Frank Erhard Uschner, Jonel Trebicka

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


Portal hypertension either develops due to progressive liver fibrosis or is the consequence of vascular liver diseases such as portal vein thrombosis or non-cirrhotic portal hypertension. This chapter focuses on different rodent models of liver fibrosis with portal hypertension and also in few non-cirrhotic portal hypertension models. Importantly, after the development of portal hypertension, the proper assessment of drug effects in the portal and systemic circulation should be discussed. The last part of the chapter is dedicated in these techniques to assess the in vivo hemodynamics and the ex vivo techniques of the isolated liver perfusion and vascular contractility.

Original languageEnglish
Title of host publicationFibrosis : Methods and Protocols
EditorsLaure Rittie
PublisherHumana Press
Publication date2017
ISBN (Print)978-1-4939-7112-1
ISBN (Electronic)978-1-4939-7113-8
Publication statusPublished - 2017
Externally publishedYes
SeriesMethods in Molecular Biology


  • Journal Article
  • Colored microsphere technique
  • Aortic ring contraction
  • Bile duct ligation
  • Carbon tetrachloride
  • High-fat diet
  • Portal hypertension
  • Isolated in situ liver perfusion
  • Partial portal vein ligation
  • Methionine-choline-deficient diet
  • Liver Cirrhosis/complications
  • Rats
  • Male
  • Mice, Knockout
  • Carbon Tetrachloride/adverse effects
  • Animals
  • Mice
  • Hemodynamics
  • Hypertension, Portal/diagnosis
  • Disease Models, Animal


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