More complications in patients with septic shock treated with dextran compared with crystalloids

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

INTRODUCTION: In recent years, the safety-profile of synthetic colloids has been questioned. The purpose of the present study was to elucidate the safety-profile of the colloid dextran-70 in relation to acute kidney injury (AKI) and death.

METHODS: We conducted a retrospective, observational study of patients admitted to our intensive care unit with septic shock and treated with dextran-70 in the period from 1 January 2009 to 31 December 2009. The controls were included from 1 March 2012 to 28 February 2013 when dextran-70 was replaced with crystalloids.

RESULTS: There were 91 patients in the dextran group and 150 patients in the non-dextran group. The urinary output was 17.93 ml/kg/24 h in the dextran group and 27.87 in the non-dextran group (p < 0.05). Continuous renal replacement therapy (CRRT) was used in 48% in the dextran group and in 23% in the non-dextran group (p < 0.05). Major bleeding episodes occurred in 32% in the dextran group compared with 15% in the control group (p < 0.05). The 90-day mortality was 42% in the dextran group and 35% in the non-dextran group (p = 0.08).

CONCLUSION: Patients in the dextran group had significantly more bleeding episodes, a higher need for CRRT and a lower urinary output than patients in the non-dextran group. Due to study design, it cannot be concluded that the use of dextran-70 is causally related to the development of AKI.

FUNDING: not relevant.

TRIAL REGISTRATION: not relevant.

Original languageEnglish
Article numberA5018
JournalDanish Medical Journal
Volume62
Issue number2
Number of pages5
ISSN2245-1919
Publication statusPublished - Feb 2015

Keywords

  • Acute Kidney Injury/chemically induced
  • Aged
  • Crystalloid Solutions
  • Dextrans/adverse effects
  • Female
  • Hemorrhage/chemically induced
  • Humans
  • Intensive Care Units
  • Isotonic Solutions/adverse effects
  • Male
  • Middle Aged
  • Plasma Substitutes/adverse effects
  • Renal Replacement Therapy/methods
  • Retrospective Studies
  • Shock, Septic/drug therapy
  • Urine

Fingerprint

Dive into the research topics of 'More complications in patients with septic shock treated with dextran compared with crystalloids'. Together they form a unique fingerprint.

Cite this