MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE

Jyothi Thyagabhavan Mony, Reza Khorooshi, Trevor Owens

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Myelin-specific T cells are implicated in multiple sclerosis (MS) and drive experimental autoimmune encephalomyelitis (EAE). EAE is commonly induced with short peptides, whereas in MS, whole myelin proteins are available for immune response. We asked whether immunization with the immunoglobulin-like domain of myelin oligodendrocyte glycoprotein (MOG(Igd), residues 1-125) might induce distinct CD4+ T-cell response and/or a stronger CD8+ T-cell response, compared to the 21 amino acid immunodominant MHC II-associating peptide (p35-55).
Original languageEnglish
JournalMultiple sclerosis
Volume20
Issue number10
Pages (from-to)1312-1321
ISSN1352-4585
DOIs
Publication statusPublished - 19. Feb 2014

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Th1 Cells
Autoimmune Experimental Encephalomyelitis
Incidence
Myelin Proteins
Peptides
Myelin Sheath
Amino Acids

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title = "MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE",
abstract = "Myelin-specific T cells are implicated in multiple sclerosis (MS) and drive experimental autoimmune encephalomyelitis (EAE). EAE is commonly induced with short peptides, whereas in MS, whole myelin proteins are available for immune response. We asked whether immunization with the immunoglobulin-like domain of myelin oligodendrocyte glycoprotein (MOG(Igd), residues 1-125) might induce distinct CD4+ T-cell response and/or a stronger CD8+ T-cell response, compared to the 21 amino acid immunodominant MHC II-associating peptide (p35-55).",
author = "{Thyagabhavan Mony}, Jyothi and Reza Khorooshi and Trevor Owens",
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language = "English",
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journal = "Multiple Sclerosis Journal",
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publisher = "SAGE Publications",
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MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE. / Thyagabhavan Mony, Jyothi; Khorooshi, Reza; Owens, Trevor.

In: Multiple sclerosis, Vol. 20, No. 10, 19.02.2014, p. 1312-1321.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE

AU - Thyagabhavan Mony, Jyothi

AU - Khorooshi, Reza

AU - Owens, Trevor

PY - 2014/2/19

Y1 - 2014/2/19

N2 - Myelin-specific T cells are implicated in multiple sclerosis (MS) and drive experimental autoimmune encephalomyelitis (EAE). EAE is commonly induced with short peptides, whereas in MS, whole myelin proteins are available for immune response. We asked whether immunization with the immunoglobulin-like domain of myelin oligodendrocyte glycoprotein (MOG(Igd), residues 1-125) might induce distinct CD4+ T-cell response and/or a stronger CD8+ T-cell response, compared to the 21 amino acid immunodominant MHC II-associating peptide (p35-55).

AB - Myelin-specific T cells are implicated in multiple sclerosis (MS) and drive experimental autoimmune encephalomyelitis (EAE). EAE is commonly induced with short peptides, whereas in MS, whole myelin proteins are available for immune response. We asked whether immunization with the immunoglobulin-like domain of myelin oligodendrocyte glycoprotein (MOG(Igd), residues 1-125) might induce distinct CD4+ T-cell response and/or a stronger CD8+ T-cell response, compared to the 21 amino acid immunodominant MHC II-associating peptide (p35-55).

U2 - 10.1177/1352458514524086

DO - 10.1177/1352458514524086

M3 - Journal article

VL - 20

SP - 1312

EP - 1321

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

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