Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

Jesper B Moeller, Irina Leonardi, Anders Schlosser, Anne-Laure Flamar, Nicholas J Bessman, Gregory Garbès Putzel, Theresa Thomsen, Mark Hammond, Christine S Jepsen, Karsten Skjødt, Ernst-Martin Füchtbauer, Donna L Farber, Grith L Sorensen, Iliyan D Iliev, Uffe Holmskov, David Artis

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Abstract

Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.

Original languageEnglish
JournalThe Journal of Experimental Medicine
Volume216
Issue number12
Pages (from-to)2689-2700
ISSN0022-1007
DOIs
Publication statusPublished - 2. Dec 2019

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Fibrinogen Receptors
Fungal Structures
Microbiota
Cell Wall
Parasites
Homeostasis
Epithelial Cells
Viruses
Mycobiome
Health

Cite this

Moeller, Jesper B ; Leonardi, Irina ; Schlosser, Anders ; Flamar, Anne-Laure ; Bessman, Nicholas J ; Putzel, Gregory Garbès ; Thomsen, Theresa ; Hammond, Mark ; Jepsen, Christine S ; Skjødt, Karsten ; Füchtbauer, Ernst-Martin ; Farber, Donna L ; Sorensen, Grith L ; Iliev, Iliyan D ; Holmskov, Uffe ; Artis, David. / Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1. In: The Journal of Experimental Medicine. 2019 ; Vol. 216, No. 12. pp. 2689-2700.
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abstract = "Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.",
author = "Moeller, {Jesper B} and Irina Leonardi and Anders Schlosser and Anne-Laure Flamar and Bessman, {Nicholas J} and Putzel, {Gregory Garb{\`e}s} and Theresa Thomsen and Mark Hammond and Jepsen, {Christine S} and Karsten Skj{\o}dt and Ernst-Martin F{\"u}chtbauer and Farber, {Donna L} and Sorensen, {Grith L} and Iliev, {Iliyan D} and Uffe Holmskov and David Artis",
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Moeller, JB, Leonardi, I, Schlosser, A, Flamar, A-L, Bessman, NJ, Putzel, GG, Thomsen, T, Hammond, M, Jepsen, CS, Skjødt, K, Füchtbauer, E-M, Farber, DL, Sorensen, GL, Iliev, ID, Holmskov, U & Artis, D 2019, 'Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1', The Journal of Experimental Medicine, vol. 216, no. 12, pp. 2689-2700. https://doi.org/10.1084/jem.20182244

Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1. / Moeller, Jesper B; Leonardi, Irina; Schlosser, Anders; Flamar, Anne-Laure; Bessman, Nicholas J; Putzel, Gregory Garbès; Thomsen, Theresa; Hammond, Mark; Jepsen, Christine S; Skjødt, Karsten; Füchtbauer, Ernst-Martin; Farber, Donna L; Sorensen, Grith L; Iliev, Iliyan D; Holmskov, Uffe; Artis, David.

In: The Journal of Experimental Medicine, Vol. 216, No. 12, 02.12.2019, p. 2689-2700.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

AU - Moeller, Jesper B

AU - Leonardi, Irina

AU - Schlosser, Anders

AU - Flamar, Anne-Laure

AU - Bessman, Nicholas J

AU - Putzel, Gregory Garbès

AU - Thomsen, Theresa

AU - Hammond, Mark

AU - Jepsen, Christine S

AU - Skjødt, Karsten

AU - Füchtbauer, Ernst-Martin

AU - Farber, Donna L

AU - Sorensen, Grith L

AU - Iliev, Iliyan D

AU - Holmskov, Uffe

AU - Artis, David

N1 - © 2019 Moeller et al.

PY - 2019/12/2

Y1 - 2019/12/2

N2 - Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.

AB - Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.

U2 - 10.1084/jem.20182244

DO - 10.1084/jem.20182244

M3 - Journal article

VL - 216

SP - 2689

EP - 2700

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 12

ER -