Modulation in time of the interictal spiking pattern related to epileptic seizures

Anca A. Arbune, Pirgit Meritam Larsen, Stephan Wüstenhagen, Daniella Terney, Elena Gardella, Sándor Beniczky*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: To test the hypothesis that significant changes in the occurrence of interictal epileptiform electroencephalography (EEG) discharges (EDs) are associated with seizures: while some EDs are pro-convulsive, increasing at seizure-occurrence, others are protective, showing decrease related to seizures. Methods: We analyzed 102 consecutive, long-term video-EEG monitoring sessions, from 98 patients. Using a semi-automated spike-detection method, we quantified the occurrence of EDs, grouped according to their location and morphology (clusters) and we constructed graphical representation of data, showing changes in time of the spiking patterns (spike-histograms). We compared the spike-histograms with the time-points of the seizures (pre-, peri- and postictal changes). Results: Totally 179 ED-clusters were identified. Modulation of the spiking pattern, associated with seizures, was observed in 66 clusters (37%), from 47 patients (48%). Most of these changes (40 clusters; 61%) were related to increase in the spiking-pattern. Conclusions: Changes in spiking-pattern were associated with more than one third of the EDs. Both increasing and decreasing patterns were observed. Significance: EDs are more often pro-convulsive, with increasing spiking patterns associated with seizures. However, in more than one third of the ED clusters modulated by seizures, the spiking pattern decreased, raising the possibility of an anticonvulsive function of these discharges.

Original languageEnglish
JournalClinical Neurophysiology
Volume132
Issue number5
Pages (from-to)1083-1088
ISSN1388-2457
DOIs
Publication statusPublished - May 2021

Bibliographical note

Publisher Copyright:
© 2021 International Federation of Clinical Neurophysiology

Keywords

  • EEG
  • Epilepsy
  • Interictal epileptiform discharges
  • Modulation
  • Seizure

Fingerprint

Dive into the research topics of 'Modulation in time of the interictal spiking pattern related to epileptic seizures'. Together they form a unique fingerprint.

Cite this