Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study

David Gaist, Ellen Garde, Morten Blaabjerg, Helle H Nielsen, Thomas Krøigård, Kamilla Østergaard, Harald S Møller, Jacob Hjelmborg, Camilla G Madsen, Pernille Iversen, Kirsten O Kyvik, Hartwig R Siebner, Messoud Ashina

Research output: Contribution to journalJournal articleResearchpeer-review

182 Downloads (Pure)

Abstract

A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura, their co-twins, and unrelated migraine-free twins (controls) were invited to a brain magnetic resonance imaging scan performed at a single centre. Brain scans were assessed for the presence of infarcts, and white matter hyperintensities (visual rating scales and volumetric analyses) blinded to headache diagnoses. Comparisons were based on 172 cases, 34 co-twins, and 139 control subjects. Compared with control subjects, cases did not differ with regard to frequency of silent brain infarcts (four cases versus one control), periventricular white matter hyperintensity scores [adjusted mean difference (95% confidence interval): -0.1 (-0.5 to 0.2)] or deep white matter hyperintensity scores [adjusted mean difference (95% confidence interval): 0.1 (-0.8 to 1.1)] assessed by Scheltens' scale. Cases had a slightly higher total white matter hyperintensity volume compared with controls [adjusted mean difference (95% confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association between silent brain infarcts, white matter hyperintensities, and migraine with aura.

Original languageEnglish
JournalBrain
Volume139
Pages (from-to)2015-2023
ISSN0006-8950
DOIs
Publication statusPublished - 2016

Fingerprint

Migraine with Aura
Confidence Intervals
Population
White Matter
Registries
Interviews
Physicians

Cite this

Gaist, David ; Garde, Ellen ; Blaabjerg, Morten ; Nielsen, Helle H ; Krøigård, Thomas ; Østergaard, Kamilla ; Møller, Harald S ; Hjelmborg, Jacob ; Madsen, Camilla G ; Iversen, Pernille ; Kyvik, Kirsten O ; Siebner, Hartwig R ; Ashina, Messoud. / Migraine with aura and risk of silent brain infarcts and white matter hyperintensities : an MRI study. In: Brain. 2016 ; Vol. 139. pp. 2015-2023.
@article{21dfdcc68ef3442abf6c7cba24ab7b7d,
title = "Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study",
abstract = "A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura, their co-twins, and unrelated migraine-free twins (controls) were invited to a brain magnetic resonance imaging scan performed at a single centre. Brain scans were assessed for the presence of infarcts, and white matter hyperintensities (visual rating scales and volumetric analyses) blinded to headache diagnoses. Comparisons were based on 172 cases, 34 co-twins, and 139 control subjects. Compared with control subjects, cases did not differ with regard to frequency of silent brain infarcts (four cases versus one control), periventricular white matter hyperintensity scores [adjusted mean difference (95{\%} confidence interval): -0.1 (-0.5 to 0.2)] or deep white matter hyperintensity scores [adjusted mean difference (95{\%} confidence interval): 0.1 (-0.8 to 1.1)] assessed by Scheltens' scale. Cases had a slightly higher total white matter hyperintensity volume compared with controls [adjusted mean difference (95{\%} confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association between silent brain infarcts, white matter hyperintensities, and migraine with aura.",
author = "David Gaist and Ellen Garde and Morten Blaabjerg and Nielsen, {Helle H} and Thomas Kr{\o}ig{\aa}rd and Kamilla {\O}stergaard and M{\o}ller, {Harald S} and Jacob Hjelmborg and Madsen, {Camilla G} and Pernille Iversen and Kyvik, {Kirsten O} and Siebner, {Hartwig R} and Messoud Ashina",
note = "{\circledC} The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.",
year = "2016",
doi = "10.1093/brain/aww099",
language = "English",
volume = "139",
pages = "2015--2023",
journal = "Brain",
issn = "0006-8950",
publisher = "Heinemann",

}

Migraine with aura and risk of silent brain infarcts and white matter hyperintensities : an MRI study. / Gaist, David; Garde, Ellen; Blaabjerg, Morten; Nielsen, Helle H; Krøigård, Thomas; Østergaard, Kamilla; Møller, Harald S; Hjelmborg, Jacob; Madsen, Camilla G; Iversen, Pernille; Kyvik, Kirsten O; Siebner, Hartwig R; Ashina, Messoud.

In: Brain, Vol. 139, 2016, p. 2015-2023.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Migraine with aura and risk of silent brain infarcts and white matter hyperintensities

T2 - an MRI study

AU - Gaist, David

AU - Garde, Ellen

AU - Blaabjerg, Morten

AU - Nielsen, Helle H

AU - Krøigård, Thomas

AU - Østergaard, Kamilla

AU - Møller, Harald S

AU - Hjelmborg, Jacob

AU - Madsen, Camilla G

AU - Iversen, Pernille

AU - Kyvik, Kirsten O

AU - Siebner, Hartwig R

AU - Ashina, Messoud

N1 - © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

PY - 2016

Y1 - 2016

N2 - A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura, their co-twins, and unrelated migraine-free twins (controls) were invited to a brain magnetic resonance imaging scan performed at a single centre. Brain scans were assessed for the presence of infarcts, and white matter hyperintensities (visual rating scales and volumetric analyses) blinded to headache diagnoses. Comparisons were based on 172 cases, 34 co-twins, and 139 control subjects. Compared with control subjects, cases did not differ with regard to frequency of silent brain infarcts (four cases versus one control), periventricular white matter hyperintensity scores [adjusted mean difference (95% confidence interval): -0.1 (-0.5 to 0.2)] or deep white matter hyperintensity scores [adjusted mean difference (95% confidence interval): 0.1 (-0.8 to 1.1)] assessed by Scheltens' scale. Cases had a slightly higher total white matter hyperintensity volume compared with controls [adjusted mean difference (95% confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association between silent brain infarcts, white matter hyperintensities, and migraine with aura.

AB - A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura, their co-twins, and unrelated migraine-free twins (controls) were invited to a brain magnetic resonance imaging scan performed at a single centre. Brain scans were assessed for the presence of infarcts, and white matter hyperintensities (visual rating scales and volumetric analyses) blinded to headache diagnoses. Comparisons were based on 172 cases, 34 co-twins, and 139 control subjects. Compared with control subjects, cases did not differ with regard to frequency of silent brain infarcts (four cases versus one control), periventricular white matter hyperintensity scores [adjusted mean difference (95% confidence interval): -0.1 (-0.5 to 0.2)] or deep white matter hyperintensity scores [adjusted mean difference (95% confidence interval): 0.1 (-0.8 to 1.1)] assessed by Scheltens' scale. Cases had a slightly higher total white matter hyperintensity volume compared with controls [adjusted mean difference (95% confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association between silent brain infarcts, white matter hyperintensities, and migraine with aura.

U2 - 10.1093/brain/aww099

DO - 10.1093/brain/aww099

M3 - Journal article

C2 - 27190013

VL - 139

SP - 2015

EP - 2023

JO - Brain

JF - Brain

SN - 0006-8950

ER -