Micro‑cantilevers for optical sensing of biogenic amines

Ying Wang, Carlos André Bravo Costa, Elżbieta Karolina Sobolewska, Jacek Fiutowski, Robert Brehm, Jörg Albers, Eric Nebling, Fabian Lofink, Bernhard Wagner, Wolfgang Benecke, Horst-Günter Rubahn, Roana Melina de Oliveira Hansen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

This paper discusses the functionalization of
micro-cantilevers in order to bind and sense specific biogenic
amines related to meat degradation (cadaverine). The
micro-cantilevers were functionalized with the composite
1,4,8,11-tetraazacyclotetradecane (cyclam), which is binding
to cadaverine molecules in the gas phase. Different
functionalization conditions were investigated by immersing
gold coated AFM cantilevers in cyclam solutions at different
concentrations, for different functionalization times,
and for different post-annealing treatments. The optimum
morphology for high capture efficiency is found for short
functionalization times without post-annealing treatment.
Beside qualitative SEM inspection which indicates a significant
morphology change for different functionalization
parameters, the impact of functionalization morphology
on analyte capture efficiency has been studied via
micro-cantilever based mass detection. We demonstrate
that besides conventional AFM systems a MEMS cantilever
in combination with an optical read out is a powerful
analytic system which is highly attractive for widespread
use in diagnostic applications, with optimized functionalization
conditions. The measured sensitivity at 7.7 kHz is
1.84 × 109 Hz/g.
Original languageEnglish
JournalMicrosystem Technologies: Micro- and Nanosystems Information Storage and Processing Systems
Volume24
Issue number1
Pages (from-to)363–369
ISSN0946-7076
DOIs
Publication statusPublished - 1. Jan 2018

Fingerprint

Cadaverine
Biogenic Amines
Amines
amines
atomic force microscopy
Annealing
annealing
Meats
microelectromechanical systems
MEMS
inspection
Gases
Inspection
vapor phases
degradation
Degradation
Scanning electron microscopy
scanning electron microscopy
Molecules
sensitivity

Cite this

Wang, Ying ; Bravo Costa, Carlos André ; Sobolewska, Elżbieta Karolina ; Fiutowski, Jacek ; Brehm, Robert ; Albers, Jörg ; Nebling, Eric ; Lofink, Fabian ; Wagner, Bernhard ; Benecke, Wolfgang ; Rubahn, Horst-Günter ; Oliveira Hansen, Roana Melina de . / Micro‑cantilevers for optical sensing of biogenic amines. In: Microsystem Technologies: Micro- and Nanosystems Information Storage and Processing Systems. 2018 ; Vol. 24, No. 1. pp. 363–369.
@article{532a819f9c654a0791e3b0287f0beab6,
title = "Micro‑cantilevers for optical sensing of biogenic amines",
abstract = "This paper discusses the functionalization ofmicro-cantilevers in order to bind and sense specific biogenicamines related to meat degradation (cadaverine). Themicro-cantilevers were functionalized with the composite1,4,8,11-tetraazacyclotetradecane (cyclam), which is bindingto cadaverine molecules in the gas phase. Differentfunctionalization conditions were investigated by immersinggold coated AFM cantilevers in cyclam solutions at differentconcentrations, for different functionalization times,and for different post-annealing treatments. The optimummorphology for high capture efficiency is found for shortfunctionalization times without post-annealing treatment.Beside qualitative SEM inspection which indicates a significantmorphology change for different functionalizationparameters, the impact of functionalization morphologyon analyte capture efficiency has been studied viamicro-cantilever based mass detection. We demonstratethat besides conventional AFM systems a MEMS cantileverin combination with an optical read out is a powerfulanalytic system which is highly attractive for widespreaduse in diagnostic applications, with optimized functionalizationconditions. The measured sensitivity at 7.7 kHz is1.84 × 109 Hz/g.",
author = "Ying Wang and {Bravo Costa}, {Carlos Andr{\'e}} and Sobolewska, {Elżbieta Karolina} and Jacek Fiutowski and Robert Brehm and J{\"o}rg Albers and Eric Nebling and Fabian Lofink and Bernhard Wagner and Wolfgang Benecke and Horst-G{\"u}nter Rubahn and {Oliveira Hansen}, {Roana Melina de}",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s00542-016-3257-9",
language = "English",
volume = "24",
pages = "363–369",
journal = "Microsystem Technologies: Micro- and Nanosystems Information Storage and Processing Systems",
issn = "0946-7076",
publisher = "Heinemann",
number = "1",

}

Micro‑cantilevers for optical sensing of biogenic amines. / Wang, Ying; Bravo Costa, Carlos André; Sobolewska, Elżbieta Karolina; Fiutowski, Jacek; Brehm, Robert ; Albers, Jörg; Nebling, Eric; Lofink, Fabian; Wagner, Bernhard; Benecke, Wolfgang; Rubahn, Horst-Günter; Oliveira Hansen, Roana Melina de .

In: Microsystem Technologies: Micro- and Nanosystems Information Storage and Processing Systems, Vol. 24, No. 1, 01.01.2018, p. 363–369.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Micro‑cantilevers for optical sensing of biogenic amines

AU - Wang, Ying

AU - Bravo Costa, Carlos André

AU - Sobolewska, Elżbieta Karolina

AU - Fiutowski, Jacek

AU - Brehm, Robert

AU - Albers, Jörg

AU - Nebling, Eric

AU - Lofink, Fabian

AU - Wagner, Bernhard

AU - Benecke, Wolfgang

AU - Rubahn, Horst-Günter

AU - Oliveira Hansen, Roana Melina de

PY - 2018/1/1

Y1 - 2018/1/1

N2 - This paper discusses the functionalization ofmicro-cantilevers in order to bind and sense specific biogenicamines related to meat degradation (cadaverine). Themicro-cantilevers were functionalized with the composite1,4,8,11-tetraazacyclotetradecane (cyclam), which is bindingto cadaverine molecules in the gas phase. Differentfunctionalization conditions were investigated by immersinggold coated AFM cantilevers in cyclam solutions at differentconcentrations, for different functionalization times,and for different post-annealing treatments. The optimummorphology for high capture efficiency is found for shortfunctionalization times without post-annealing treatment.Beside qualitative SEM inspection which indicates a significantmorphology change for different functionalizationparameters, the impact of functionalization morphologyon analyte capture efficiency has been studied viamicro-cantilever based mass detection. We demonstratethat besides conventional AFM systems a MEMS cantileverin combination with an optical read out is a powerfulanalytic system which is highly attractive for widespreaduse in diagnostic applications, with optimized functionalizationconditions. The measured sensitivity at 7.7 kHz is1.84 × 109 Hz/g.

AB - This paper discusses the functionalization ofmicro-cantilevers in order to bind and sense specific biogenicamines related to meat degradation (cadaverine). Themicro-cantilevers were functionalized with the composite1,4,8,11-tetraazacyclotetradecane (cyclam), which is bindingto cadaverine molecules in the gas phase. Differentfunctionalization conditions were investigated by immersinggold coated AFM cantilevers in cyclam solutions at differentconcentrations, for different functionalization times,and for different post-annealing treatments. The optimummorphology for high capture efficiency is found for shortfunctionalization times without post-annealing treatment.Beside qualitative SEM inspection which indicates a significantmorphology change for different functionalizationparameters, the impact of functionalization morphologyon analyte capture efficiency has been studied viamicro-cantilever based mass detection. We demonstratethat besides conventional AFM systems a MEMS cantileverin combination with an optical read out is a powerfulanalytic system which is highly attractive for widespreaduse in diagnostic applications, with optimized functionalizationconditions. The measured sensitivity at 7.7 kHz is1.84 × 109 Hz/g.

U2 - 10.1007/s00542-016-3257-9

DO - 10.1007/s00542-016-3257-9

M3 - Journal article

VL - 24

SP - 363

EP - 369

JO - Microsystem Technologies: Micro- and Nanosystems Information Storage and Processing Systems

JF - Microsystem Technologies: Micro- and Nanosystems Information Storage and Processing Systems

SN - 0946-7076

IS - 1

ER -