MI (2-methyl-4-isothiazolin-3-one) contained in detergents is not detectable in machine washed textiles

Maja A Hofmann, Ana Giménez-Arnau, Werner Aberer, Carsten Bindslev-Jensen, Torsten Zuberbier

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Background: European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to determine the risk of MI in laundry detergents for household machine washing.

Methods: Different formulations of laundry detergents with commercial MI levels, up to one thousand ppm were used and three different types of clothes were washed in a normal household machine setting one time and 10 times. The level of MI was measured by HPLC.

Results: While MI could be retrieved in the positive control of clothes drenched with washing powder but not washed afterwards, MI could not be detected in any specimen of clothes washed under household conditions. The detection limit was 0.5 ppm.

Conclusion: It is important to discuss the difference of risk and hazard. While MI clearly is a high hazard as a strong contact allergen, the risk depends on exposure. Regarding the risk of exposure levels for the consumer to MI in clothes it can be stated that the use of MI in laundry detergents is safe for the consumer if these products are used according to the instructions in the normal household setting machine wash.

Original languageEnglish
Article number1
JournalClinical and Translational Allergy
Volume8
Number of pages6
ISSN2045-7022
DOIs
Publication statusPublished - 1. Jan 2018

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2-methyl-4-isothiazolin-3-one
Legislation
Powders
Allergens
Limit of Detection
Hypersensitivity
High Pressure Liquid Chromatography

Keywords

  • Contact allergy
  • Laundry detergent
  • MI
  • Preservative

Cite this

@article{f42fde0a724148f79012858dfbc50c81,
title = "MI (2-methyl-4-isothiazolin-3-one) contained in detergents is not detectable in machine washed textiles",
abstract = "Background: European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to determine the risk of MI in laundry detergents for household machine washing.Methods: Different formulations of laundry detergents with commercial MI levels, up to one thousand ppm were used and three different types of clothes were washed in a normal household machine setting one time and 10 times. The level of MI was measured by HPLC.Results: While MI could be retrieved in the positive control of clothes drenched with washing powder but not washed afterwards, MI could not be detected in any specimen of clothes washed under household conditions. The detection limit was 0.5 ppm.Conclusion: It is important to discuss the difference of risk and hazard. While MI clearly is a high hazard as a strong contact allergen, the risk depends on exposure. Regarding the risk of exposure levels for the consumer to MI in clothes it can be stated that the use of MI in laundry detergents is safe for the consumer if these products are used according to the instructions in the normal household setting machine wash.",
keywords = "Contact allergy, Laundry detergent, MI, Preservative",
author = "Hofmann, {Maja A} and Ana Gim{\'e}nez-Arnau and Werner Aberer and Carsten Bindslev-Jensen and Torsten Zuberbier",
year = "2018",
month = "1",
day = "1",
doi = "10.1186/s13601-017-0187-2",
language = "English",
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journal = "Clinical and Translational Allergy",
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publisher = "BioMed Central",

}

MI (2-methyl-4-isothiazolin-3-one) contained in detergents is not detectable in machine washed textiles. / Hofmann, Maja A; Giménez-Arnau, Ana; Aberer, Werner; Bindslev-Jensen, Carsten; Zuberbier, Torsten.

In: Clinical and Translational Allergy, Vol. 8, 1, 01.01.2018.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - MI (2-methyl-4-isothiazolin-3-one) contained in detergents is not detectable in machine washed textiles

AU - Hofmann, Maja A

AU - Giménez-Arnau, Ana

AU - Aberer, Werner

AU - Bindslev-Jensen, Carsten

AU - Zuberbier, Torsten

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to determine the risk of MI in laundry detergents for household machine washing.Methods: Different formulations of laundry detergents with commercial MI levels, up to one thousand ppm were used and three different types of clothes were washed in a normal household machine setting one time and 10 times. The level of MI was measured by HPLC.Results: While MI could be retrieved in the positive control of clothes drenched with washing powder but not washed afterwards, MI could not be detected in any specimen of clothes washed under household conditions. The detection limit was 0.5 ppm.Conclusion: It is important to discuss the difference of risk and hazard. While MI clearly is a high hazard as a strong contact allergen, the risk depends on exposure. Regarding the risk of exposure levels for the consumer to MI in clothes it can be stated that the use of MI in laundry detergents is safe for the consumer if these products are used according to the instructions in the normal household setting machine wash.

AB - Background: European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to determine the risk of MI in laundry detergents for household machine washing.Methods: Different formulations of laundry detergents with commercial MI levels, up to one thousand ppm were used and three different types of clothes were washed in a normal household machine setting one time and 10 times. The level of MI was measured by HPLC.Results: While MI could be retrieved in the positive control of clothes drenched with washing powder but not washed afterwards, MI could not be detected in any specimen of clothes washed under household conditions. The detection limit was 0.5 ppm.Conclusion: It is important to discuss the difference of risk and hazard. While MI clearly is a high hazard as a strong contact allergen, the risk depends on exposure. Regarding the risk of exposure levels for the consumer to MI in clothes it can be stated that the use of MI in laundry detergents is safe for the consumer if these products are used according to the instructions in the normal household setting machine wash.

KW - Contact allergy

KW - Laundry detergent

KW - MI

KW - Preservative

U2 - 10.1186/s13601-017-0187-2

DO - 10.1186/s13601-017-0187-2

M3 - Journal article

C2 - 29312657

VL - 8

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

SN - 2045-7022

M1 - 1

ER -