Metformin og kirurgi i generel anæstesi

Translated title of the contribution: Metformin and surgery before general anaesthesia

Elisabeth Lauritzen, David Hebbelstrup Jensen, Christian Bonde, Henning Beck-Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Danish national guidelines recommend discontinuation of metformin 48 h prior to general anaesthesia due to the presumed increased risk of lactic acidosis. By reviewing recent studies concerning the risk of metformin-associated lactic acidosis it is found, that studies indicate, that metformin does not increase the risk of lactic acidosis. However, comorbidities such as cardiovascular insufficiency, sepsis, dehydration and impaired kidney function are risk factors. New guidelines propose discontinuation of metformin on the day of surgery. Patients with Type 2 diabetes and comorbidities should have the levels of arterial pH and lactate monitored.
Original languageDanish
Article numberV08180593
JournalUgeskrift for Laeger
Volume181
Issue number17
ISSN0041-5782
Publication statusPublished - 2019

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Lactic Acidosis
Comorbidity
Guidelines
Ambulatory Surgical Procedures
Dehydration
Type 2 Diabetes Mellitus
Lactic Acid
Kidney

Cite this

Lauritzen, E., Jensen, D. H., Bonde, C., & Beck-Nielsen, H. (2019). Metformin og kirurgi i generel anæstesi. Ugeskrift for Laeger, 181(17), [V08180593].
Lauritzen, Elisabeth ; Jensen, David Hebbelstrup ; Bonde, Christian ; Beck-Nielsen, Henning. / Metformin og kirurgi i generel anæstesi. In: Ugeskrift for Laeger. 2019 ; Vol. 181, No. 17.
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title = "Metformin og kirurgi i generel an{\ae}stesi",
abstract = "Danish national guidelines recommend discontinuation of metformin 48 h prior to general anaesthesia due to the presumed increased risk of lactic acidosis. By reviewing recent studies concerning the risk of metformin-associated lactic acidosis it is found, that studies indicate, that metformin does not increase the risk of lactic acidosis. However, comorbidities such as cardiovascular insufficiency, sepsis, dehydration and impaired kidney function are risk factors. New guidelines propose discontinuation of metformin on the day of surgery. Patients with Type 2 diabetes and comorbidities should have the levels of arterial pH and lactate monitored.",
author = "Elisabeth Lauritzen and Jensen, {David Hebbelstrup} and Christian Bonde and Henning Beck-Nielsen",
year = "2019",
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Lauritzen, E, Jensen, DH, Bonde, C & Beck-Nielsen, H 2019, 'Metformin og kirurgi i generel anæstesi', Ugeskrift for Laeger, vol. 181, no. 17, V08180593.

Metformin og kirurgi i generel anæstesi. / Lauritzen, Elisabeth; Jensen, David Hebbelstrup; Bonde, Christian; Beck-Nielsen, Henning.

In: Ugeskrift for Laeger, Vol. 181, No. 17, V08180593, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Metformin og kirurgi i generel anæstesi

AU - Lauritzen, Elisabeth

AU - Jensen, David Hebbelstrup

AU - Bonde, Christian

AU - Beck-Nielsen, Henning

PY - 2019

Y1 - 2019

N2 - Danish national guidelines recommend discontinuation of metformin 48 h prior to general anaesthesia due to the presumed increased risk of lactic acidosis. By reviewing recent studies concerning the risk of metformin-associated lactic acidosis it is found, that studies indicate, that metformin does not increase the risk of lactic acidosis. However, comorbidities such as cardiovascular insufficiency, sepsis, dehydration and impaired kidney function are risk factors. New guidelines propose discontinuation of metformin on the day of surgery. Patients with Type 2 diabetes and comorbidities should have the levels of arterial pH and lactate monitored.

AB - Danish national guidelines recommend discontinuation of metformin 48 h prior to general anaesthesia due to the presumed increased risk of lactic acidosis. By reviewing recent studies concerning the risk of metformin-associated lactic acidosis it is found, that studies indicate, that metformin does not increase the risk of lactic acidosis. However, comorbidities such as cardiovascular insufficiency, sepsis, dehydration and impaired kidney function are risk factors. New guidelines propose discontinuation of metformin on the day of surgery. Patients with Type 2 diabetes and comorbidities should have the levels of arterial pH and lactate monitored.

M3 - Tidsskriftartikel

VL - 181

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 17

M1 - V08180593

ER -

Lauritzen E, Jensen DH, Bonde C, Beck-Nielsen H. Metformin og kirurgi i generel anæstesi. Ugeskrift for Laeger. 2019;181(17). V08180593.