Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database: A Validation Study

Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Siri Klausen, Anton Pottegård, Søren Friis, Lisbet Rosenkrantz Hölmich, David Gaist

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Abstract

Background: The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance, and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. Methods: We estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n = 200) and the Melanoma Database (n = 200) during 2004-2014, using the Danish Pathology Registry as "gold standard" reference. We further validated tumor characteristics in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014. Results: The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97% (95% CI = 94, 99) and 100%. The sensitivity was 90% in the Cancer Registry and 77% in the Melanoma Database. The PPV of in situ melanomas in the Melanoma Database was 97% and the sensitivity was 56%. In the Melanoma Database, we observed PPVs of ulceration of 75% and Breslow thickness of 96%. The PPV of histologic subtypes varied between 87% and 100% in the Cancer Registry and 93% and 100% in the Melanoma Database. The PPVs for anatomical localization were 83%-95% in the Cancer Registry and 93%-100% in the Melanoma Database. Conclusions: The data quality in both the Cancer Registry and the Melanoma Database is high, supporting their use in epidemiologic studies.

Original languageEnglish
JournalEpidemiology
Volume29
Issue number3
Pages (from-to)442-447
ISSN1044-3983
DOIs
Publication statusPublished - May 2018

Fingerprint

Validation Studies
Registries
Melanoma
Databases
Skin
Neoplasms

Keywords

  • Aged
  • Databases, Factual/standards
  • Denmark/epidemiology
  • Female
  • Humans
  • Male
  • Melanoma/epidemiology
  • Middle Aged
  • Registries/standards
  • Skin/physiopathology

Cite this

Pedersen, Sidsel Arnspang ; Schmidt, Sigrun Alba Johannesdottir ; Klausen, Siri ; Pottegård, Anton ; Friis, Søren ; Hölmich, Lisbet Rosenkrantz ; Gaist, David. / Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database : A Validation Study. In: Epidemiology. 2018 ; Vol. 29, No. 3. pp. 442-447.
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title = "Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database: A Validation Study",
abstract = "Background: The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance, and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. Methods: We estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n = 200) and the Melanoma Database (n = 200) during 2004-2014, using the Danish Pathology Registry as {"}gold standard{"} reference. We further validated tumor characteristics in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014. Results: The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97{\%} (95{\%} CI = 94, 99) and 100{\%}. The sensitivity was 90{\%} in the Cancer Registry and 77{\%} in the Melanoma Database. The PPV of in situ melanomas in the Melanoma Database was 97{\%} and the sensitivity was 56{\%}. In the Melanoma Database, we observed PPVs of ulceration of 75{\%} and Breslow thickness of 96{\%}. The PPV of histologic subtypes varied between 87{\%} and 100{\%} in the Cancer Registry and 93{\%} and 100{\%} in the Melanoma Database. The PPVs for anatomical localization were 83{\%}-95{\%} in the Cancer Registry and 93{\%}-100{\%} in the Melanoma Database. Conclusions: The data quality in both the Cancer Registry and the Melanoma Database is high, supporting their use in epidemiologic studies.",
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author = "Pedersen, {Sidsel Arnspang} and Schmidt, {Sigrun Alba Johannesdottir} and Siri Klausen and Anton Potteg{\aa}rd and S{\o}ren Friis and H{\"o}lmich, {Lisbet Rosenkrantz} and David Gaist",
year = "2018",
month = "5",
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Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database : A Validation Study. / Pedersen, Sidsel Arnspang; Schmidt, Sigrun Alba Johannesdottir; Klausen, Siri; Pottegård, Anton; Friis, Søren; Hölmich, Lisbet Rosenkrantz; Gaist, David.

In: Epidemiology, Vol. 29, No. 3, 05.2018, p. 442-447.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database

T2 - A Validation Study

AU - Pedersen, Sidsel Arnspang

AU - Schmidt, Sigrun Alba Johannesdottir

AU - Klausen, Siri

AU - Pottegård, Anton

AU - Friis, Søren

AU - Hölmich, Lisbet Rosenkrantz

AU - Gaist, David

PY - 2018/5

Y1 - 2018/5

N2 - Background: The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance, and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. Methods: We estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n = 200) and the Melanoma Database (n = 200) during 2004-2014, using the Danish Pathology Registry as "gold standard" reference. We further validated tumor characteristics in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014. Results: The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97% (95% CI = 94, 99) and 100%. The sensitivity was 90% in the Cancer Registry and 77% in the Melanoma Database. The PPV of in situ melanomas in the Melanoma Database was 97% and the sensitivity was 56%. In the Melanoma Database, we observed PPVs of ulceration of 75% and Breslow thickness of 96%. The PPV of histologic subtypes varied between 87% and 100% in the Cancer Registry and 93% and 100% in the Melanoma Database. The PPVs for anatomical localization were 83%-95% in the Cancer Registry and 93%-100% in the Melanoma Database. Conclusions: The data quality in both the Cancer Registry and the Melanoma Database is high, supporting their use in epidemiologic studies.

AB - Background: The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance, and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. Methods: We estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n = 200) and the Melanoma Database (n = 200) during 2004-2014, using the Danish Pathology Registry as "gold standard" reference. We further validated tumor characteristics in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014. Results: The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97% (95% CI = 94, 99) and 100%. The sensitivity was 90% in the Cancer Registry and 77% in the Melanoma Database. The PPV of in situ melanomas in the Melanoma Database was 97% and the sensitivity was 56%. In the Melanoma Database, we observed PPVs of ulceration of 75% and Breslow thickness of 96%. The PPV of histologic subtypes varied between 87% and 100% in the Cancer Registry and 93% and 100% in the Melanoma Database. The PPVs for anatomical localization were 83%-95% in the Cancer Registry and 93%-100% in the Melanoma Database. Conclusions: The data quality in both the Cancer Registry and the Melanoma Database is high, supporting their use in epidemiologic studies.

KW - Aged

KW - Databases, Factual/standards

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Male

KW - Melanoma/epidemiology

KW - Middle Aged

KW - Registries/standards

KW - Skin/physiopathology

U2 - 10.1097/EDE.0000000000000802

DO - 10.1097/EDE.0000000000000802

M3 - Journal article

C2 - 29337844

VL - 29

SP - 442

EP - 447

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 3

ER -