Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation

Helene Skjøt-Arkil, Rikke E Clausen, Quoc Hai Trieu Nguyen, Yaguo Wang, Qinlong Zheng, Fernando J Martinez, Cory M Hogaboam, Meilan Han, Lloyd B Klickstein, Martin Røssel Larsen, Arkadiusz Nawrocki, Diana Julie Leeming, Morten A Karsdal

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Elastin is an essential component of selected connective tissues that provides a unique physiological elasticity. Elastin may be considered a signature protein of lungs where matrix metalloprotease (MMP) -9-and -12, may be considered the signature proteases of the macrophages, which in part are responsible for tissue damage during disease progression. Thus, we hypothesized that a MMP-9/-12 generated fragment of elastin may be a relevant biochemical maker for lung diseases.
Original languageEnglish
JournalB M C Pulmonary Medicine
Volume12
Pages (from-to)34
ISSN1471-2466
DOIs
Publication statusPublished - 2012

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