Maternal measles antibodies and their influence on all-cause mortality following measles vaccination

an alternative to measure very low maternal antibody levels

Gaby Smits, Christine Stabell Benn, Hilton Whittle, Rob van Binnendijk, Peter Aaby, Fiona van der Klis

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality (P = .02).

Original languageEnglish
JournalClinical Infectious Diseases
Volume68
Issue number10
Pages (from-to)1758-1760
ISSN1058-4838
DOIs
Publication statusPublished - 2. May 2019

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Measles
Mothers
Immunoassay

Keywords

  • All-causemortality
  • HAI
  • Maternalmeaslesantibodies
  • Multiplex immunoassay

Cite this

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title = "Maternal measles antibodies and their influence on all-cause mortality following measles vaccination: an alternative to measure very low maternal antibody levels",
abstract = "It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality (P = .02).",
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Maternal measles antibodies and their influence on all-cause mortality following measles vaccination : an alternative to measure very low maternal antibody levels. / Smits, Gaby; Stabell Benn, Christine; Whittle, Hilton; van Binnendijk, Rob; Aaby, Peter; van der Klis, Fiona.

In: Clinical Infectious Diseases, Vol. 68, No. 10, 02.05.2019, p. 1758-1760.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

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AU - Smits, Gaby

AU - Stabell Benn, Christine

AU - Whittle, Hilton

AU - van Binnendijk, Rob

AU - Aaby, Peter

AU - van der Klis, Fiona

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AB - It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality (P = .02).

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KW - HAI

KW - Maternalmeaslesantibodies

KW - Multiplex immunoassay

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DO - 10.1093/cid/ciy900

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JO - Clinical Infectious Diseases

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