Management of Cancer-Associated Venous Thrombosis: A Nationwide Survey among Danish Oncologists

Anette Arbjerg Højen, Thure Filskov Overvad, Mads Nybo, Thomas Kümler, Morten Schnack Rasmussen, Thomas Decker Christensen, Torben Bjerregaard Larsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background  Treatment patterns for cancer-associated venous thrombosis (CAT) has been shown to be nonconsistent with contemporary guideline recommendations, resulting in poor patient outcomes. Objectives  The study aimed to describe contemporary CAT management in Danish oncology departments and identify knowledge gaps and inconsistencies between guidelines and clinical practice. Patients and Methods  A survey questionnaire in Danish was developed based on contemporary national guidelines. Using an open recruitment strategy, invitations to participate in the electronic survey were sent to physicians employed at oncology departments in Denmark in winter of 2018/2019. The questionnaire was based on current national guidelines and included 10 items with multiple choices and a free-text option to specify or comment. The questionnaire was pilot-tested by a junior and senior oncologist. Results  A total of 142 physicians completed the survey, representing all Danish geographical regions and various seniority. The majority reported that CAT was treated and followed up in oncology departments. However, 36.6% of the physicians were unaware of the existence of designated cancer thrombosis guidelines. Risk of venous thrombosis was generally assessed without diagnostic scores. Almost all (98.6%) reported low-molecular-weight heparin to be first-line treatment for CAT. Treatment duration seemed wrongly influenced by subtype of venous thrombosis, and 44.5% responded that thromboprophylaxis among hospitalized patients was substantially underused. Conclusion  The variability in the daily clinical management of CAT demonstrated through this survey indicates a potential to increase awareness of available guidelines, standardized use of inpatient thromboprophylaxis, and organized treatment and follow-up in a multidisciplinary setting, which would potentially improve management of CAT in Denmark.

Original languageEnglish
Journal Thrombosis and Haemostasis Open
Volume5
Issue number2
Pages (from-to)e188-e194
ISSN2512-9465
DOIs
Publication statusPublished - Apr 2021

Bibliographical note

The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).

Fingerprint

Dive into the research topics of 'Management of Cancer-Associated Venous Thrombosis: A Nationwide Survey among Danish Oncologists'. Together they form a unique fingerprint.

Cite this