Magnetic resonance elastography in normal pressure hydrocephalus—a scoping review

Jan Saip Aunan-Diop*, Christian Bonde Pedersen, Bo Halle, Ulla Jensen, Sune Munthe, Fredrik Harbo, Bjarni Johannsson, Frantz Rom Poulsen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Background: Magnetic resonance elastography (MRE) of the brain allows quantitative measurement of tissue mechanics. Multiple studies are exploring possible applications in normal pressure hydrocephalus (NPH) in clinical and paraclinical contexts. This is of great interest in neurological surgery due to challenges related to diagnosis and prediction of treatment effects. In this scoping review, we present a topical overview and discuss the current literature, with particular attention to clinical implications and current challenges. Methods: The protocol was based on the PRISMA extension for scoping reviews. After a systematic database search (PubMed, Embase, and Web of Science), the articles were screened for relevance. Thirty articles were subject to detailed screening, and key technical and clinical data items were extracted. The inclusion criteria included the use of MRE on human subjects with NPH. Results: Seven articles were included in the final study. These studies had various objectives including the role of MRE in the assessment of regional elastic changes in NPH, shunt effect, and evaluation of NPH symptoms. MRE revealed patterns of mechanical changes in NPH that differed from other dementias. Regional MRE changes were associated with specific NPH signs and symptoms. Neurosurgical shunting caused partial normalization in tissue scaffold parameters. The studies were highly heterogeneous in technical aspects and design. Conclusion: MRE studies in NPH are still limited by few participants, variable cohorts, inconsistent methodologies, and technical challenges, but the approach shows great potential for future clinical application.

Original languageEnglish
JournalNeurosurgical Review
Issue number2
Pages (from-to)1157-1169
Publication statusPublished - Apr 2022


  • Elasticity
  • Magnetic resonance elastography
  • Neurosurgery
  • Normal pressure hydrocephalus
  • Stiffness
  • Viscoelasticity
  • Brain/diagnostic imaging
  • Elasticity Imaging Techniques/methods
  • Humans
  • Magnetic Resonance Imaging/methods
  • Hydrocephalus, Normal Pressure/diagnostic imaging


Dive into the research topics of 'Magnetic resonance elastography in normal pressure hydrocephalus—a scoping review'. Together they form a unique fingerprint.

Cite this