Lung function in 6 years old children born very preterm and fed different diets post discharge

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Research has shown that being born preterm may affect lung capacity later in childhood. It is though unknown if type of early nutrition influences lung capacity and the risk of developing asthma in childhood.

The aim was to investigate if type of early nutrition has an impact on lung function and the possible risk of developing asthma among 6 year old children born very preterm.

A prospective, randomized, interventional multicentre study on nutrition of a preterm birth cohort has been established and described previously. The inclusion criteria were gestational age ≤ 32 weeks. From hospital discharge to 4 month corrected age, the children received three different types of nutrition: A: Human milk (HM) B: HM enriched with fortifier (HMF) C: Preterm formula (PF). At the age of 6 years, the children performed an occlusion test (Rocc) and a lung resistance test (SRtot). The mean of both Rocc and SRtot was calculated

277 children are included in this project. So far 111 children have performed the lung function tests (Group A: 37 B: 35 C: 39 respectively). The results from the Rocc-test were very similar comparing the groups with no significant differences: A: 1.05 B: 1.05 C: 1.04 (kPa*s/L);. The SRtot test showed that group B and C had a significant lower value compared to group A: A 1.21 B: 0.98 C: 1.01 (kPa*s). P-value = 0,007 when comparing A and C, and p-value = 0,03 when A compares to B.

This preliminary result indicates that airway resistance was within normal range for all children no mater post discharge nutrition. And there was a tendency towards a lower airway resistance among infants fed with formula or nutrient enriched human milk compared to infants fed exclusively human milk post discharge.
Translated title of the contributionLungefunktion hos 6 årige børn født meget prætermt set i forhold til den tidlige ernæring.
Original languageEnglish
Publication date17. Oct 2014
Number of pages1
Publication statusPublished - 17. Oct 2014
Event5th Congress of the European Academy of Paediatric Societies - Barcelona, Spain
Duration: 17. Oct 201421. Oct 2014
Conference number: 5


Conference5th Congress of the European Academy of Paediatric Societies
  • Eorupean academy of pediatrics

    Line Hedegaard Toftlund (Participant)

    17. Oct 201421. Oct 2014

    Activity: Attending an eventConference organisation or participation

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