Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data

Jacob K Pedersen, Axel Skytthe, Matt McGue, Lawrence S Honig, Claudio Franceschi, Thomas B L Kirkwood, Giuseppe Passarino, P Eline Slagboom, James W Vaupel, Kaare Christensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific cancers is a mechanism for familial clustering of longevity.

METHODS: The study population of individuals from longevity-enriched families consisted of 3267 offspring from 610 Danish long-lived families defined by two siblings attaining an age of 90 years or more. The offspring of the long-lived siblings were followed from 1968 to 2009. Using high-quality registry data, observed numbers of cancers were compared with expected numbers based on gender-, calendar period-, and age-specific incidence rates in the general population.

RESULTS: During the 41-year-follow-up period, a total of 423 cancers occurred in 397 individuals. The standardized incidence ratios (95% confidence interval) for offspring of long-lived individuals were 0.78 (0.70-0.86) for overall cancer; 0.66 (0.56-0.77) for tobacco-related cancer; 0.34 (0.22-0.51) for lung cancer; 0.88 (0.71-1.10) for breast cancer; 0.91 (0.62-1.34) for colon cancer.

CONCLUSIONS: The low incidence of tobacco-related cancers in long-lived families compared with non-tobacco-related cancers suggests that health behavior plays a central role in lower early cancer incidence in offspring of long-lived siblings in Denmark.

Original languageEnglish
JournalAnnals of Epidemiology
Volume25
Issue number8
Pages (from-to)569-574.e3
ISSN1047-2797
DOIs
Publication statusPublished - Aug 2015

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Registries
Incidence
Neoplasms
Cluster Analysis
Health Behavior
Denmark
Colonic Neoplasms
Population
Confidence Intervals

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@article{d415593506fd4502911abb272b5ef2b5,
title = "Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data",
abstract = "PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific cancers is a mechanism for familial clustering of longevity.METHODS: The study population of individuals from longevity-enriched families consisted of 3267 offspring from 610 Danish long-lived families defined by two siblings attaining an age of 90 years or more. The offspring of the long-lived siblings were followed from 1968 to 2009. Using high-quality registry data, observed numbers of cancers were compared with expected numbers based on gender-, calendar period-, and age-specific incidence rates in the general population.RESULTS: During the 41-year-follow-up period, a total of 423 cancers occurred in 397 individuals. The standardized incidence ratios (95{\%} confidence interval) for offspring of long-lived individuals were 0.78 (0.70-0.86) for overall cancer; 0.66 (0.56-0.77) for tobacco-related cancer; 0.34 (0.22-0.51) for lung cancer; 0.88 (0.71-1.10) for breast cancer; 0.91 (0.62-1.34) for colon cancer.CONCLUSIONS: The low incidence of tobacco-related cancers in long-lived families compared with non-tobacco-related cancers suggests that health behavior plays a central role in lower early cancer incidence in offspring of long-lived siblings in Denmark.",
author = "Pedersen, {Jacob K} and Axel Skytthe and Matt McGue and Honig, {Lawrence S} and Claudio Franceschi and Kirkwood, {Thomas B L} and Giuseppe Passarino and Slagboom, {P Eline} and Vaupel, {James W} and Kaare Christensen",
note = "Copyright {\circledC} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = "8",
doi = "10.1016/j.annepidem.2015.03.004",
language = "English",
volume = "25",
pages = "569--574.e3",
journal = "Annals of Epidemiology",
issn = "1047-2797",
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Low tobacco-related cancer incidence in offspring of long-lived siblings : a comparison with Danish national cancer registry data. / Pedersen, Jacob K; Skytthe, Axel; McGue, Matt; Honig, Lawrence S; Franceschi, Claudio; Kirkwood, Thomas B L; Passarino, Giuseppe; Slagboom, P Eline; Vaupel, James W; Christensen, Kaare.

In: Annals of Epidemiology, Vol. 25, No. 8, 08.2015, p. 569-574.e3.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Low tobacco-related cancer incidence in offspring of long-lived siblings

T2 - a comparison with Danish national cancer registry data

AU - Pedersen, Jacob K

AU - Skytthe, Axel

AU - McGue, Matt

AU - Honig, Lawrence S

AU - Franceschi, Claudio

AU - Kirkwood, Thomas B L

AU - Passarino, Giuseppe

AU - Slagboom, P Eline

AU - Vaupel, James W

AU - Christensen, Kaare

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/8

Y1 - 2015/8

N2 - PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific cancers is a mechanism for familial clustering of longevity.METHODS: The study population of individuals from longevity-enriched families consisted of 3267 offspring from 610 Danish long-lived families defined by two siblings attaining an age of 90 years or more. The offspring of the long-lived siblings were followed from 1968 to 2009. Using high-quality registry data, observed numbers of cancers were compared with expected numbers based on gender-, calendar period-, and age-specific incidence rates in the general population.RESULTS: During the 41-year-follow-up period, a total of 423 cancers occurred in 397 individuals. The standardized incidence ratios (95% confidence interval) for offspring of long-lived individuals were 0.78 (0.70-0.86) for overall cancer; 0.66 (0.56-0.77) for tobacco-related cancer; 0.34 (0.22-0.51) for lung cancer; 0.88 (0.71-1.10) for breast cancer; 0.91 (0.62-1.34) for colon cancer.CONCLUSIONS: The low incidence of tobacco-related cancers in long-lived families compared with non-tobacco-related cancers suggests that health behavior plays a central role in lower early cancer incidence in offspring of long-lived siblings in Denmark.

AB - PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific cancers is a mechanism for familial clustering of longevity.METHODS: The study population of individuals from longevity-enriched families consisted of 3267 offspring from 610 Danish long-lived families defined by two siblings attaining an age of 90 years or more. The offspring of the long-lived siblings were followed from 1968 to 2009. Using high-quality registry data, observed numbers of cancers were compared with expected numbers based on gender-, calendar period-, and age-specific incidence rates in the general population.RESULTS: During the 41-year-follow-up period, a total of 423 cancers occurred in 397 individuals. The standardized incidence ratios (95% confidence interval) for offspring of long-lived individuals were 0.78 (0.70-0.86) for overall cancer; 0.66 (0.56-0.77) for tobacco-related cancer; 0.34 (0.22-0.51) for lung cancer; 0.88 (0.71-1.10) for breast cancer; 0.91 (0.62-1.34) for colon cancer.CONCLUSIONS: The low incidence of tobacco-related cancers in long-lived families compared with non-tobacco-related cancers suggests that health behavior plays a central role in lower early cancer incidence in offspring of long-lived siblings in Denmark.

U2 - 10.1016/j.annepidem.2015.03.004

DO - 10.1016/j.annepidem.2015.03.004

M3 - Journal article

C2 - 25890797

VL - 25

SP - 569-574.e3

JO - Annals of Epidemiology

JF - Annals of Epidemiology

SN - 1047-2797

IS - 8

ER -