Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2

Camilla Heldbjerg Drabe*, Ann Brit Eg Hansen, Line Dahlerup Rasmussen, Olav Ditlevsen Larsen, Axel Møller, Trine H. Mogensen, Jannik Helweg-Larsen, Terese L. Katzenstein

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID). Methods: A Danish nationwide retrospective clinician-reported survey. Results: Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22–72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered. Conclusions: The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.

Original languageEnglish
JournalInfectious Diseases
Volume53
Issue number12
Pages (from-to)953-958
ISSN2374-4235
DOIs
Publication statusPublished - 11. Aug 2021

Keywords

  • common variable immunodeficiency
  • COVID-19
  • inborn errors of immunity
  • primary immunodeficiency
  • SARS-CoV-2
  • Common Variable Immunodeficiency/complications
  • Humans
  • Middle Aged
  • Morbidity
  • Young Adult
  • Denmark/epidemiology
  • Adult
  • Aged
  • Retrospective Studies

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