Longitudinal Changes in Leukocyte Telomere Length and Mortality in Humans

Laila Bendix; Mikael Thinggaard; Mogens Fenger; Steen Kølvraa; Kirsten Avlund; Allan René Linneberg; Merete Osler

doi:10.1093/gerona/glt153

Longitudinal Changes in Leukocyte Telomere Length and Mortality in Humans

Laila Bendix, Mikael Thinggaard, Mogens Fenger, Steen Kølvraa, Kirsten Avlund, Allan René Linneberg, Merete Osler

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Leukocyte telomere length (LTL) ostensibly shortens with age and has been moderately associated with mortality. In humans, these findings have come almost solely from cross-sectional studies. Only recently has LTL shortening within individuals been analyzed in longitudinal studies. Such studies are relevant to establish LTL dynamics as biomarkers of mortality as well as to disentangle the causality of telomeres on aging.

Original language	English
Journal	The journals of gerontology. Series A, Biological sciences and medical sciences
Volume	69 A
Issue number	2
Pages (from-to)	231-239
ISSN	1079-5006
DOIs	https://doi.org/10.1093/gerona/glt153
Publication status	Published - Feb 2014

Keywords

Biomarkers
DNA damage and repair
Epidemiology
Longevity
Life Style
Age Factors
Humans
Middle Aged
Risk Factors
Longevity/physiology
Male
Alcohol Drinking
Socioeconomic Factors
Telomere Shortening/physiology
Adult
Female
Aged
Leukocytes/pathology
Health Status
Longitudinal Studies
Smoking

Documents & Links

10.1093/gerona/glt153

Cite this

@article{7652ed9568ac4d6a92490346756b5ad2,

title = "Longitudinal Changes in Leukocyte Telomere Length and Mortality in Humans",

abstract = "Leukocyte telomere length (LTL) ostensibly shortens with age and has been moderately associated with mortality. In humans, these findings have come almost solely from cross-sectional studies. Only recently has LTL shortening within individuals been analyzed in longitudinal studies. Such studies are relevant to establish LTL dynamics as biomarkers of mortality as well as to disentangle the causality of telomeres on aging.",

keywords = "Biomarkers, Longevity, DNA damage and repair, Epidemiology, Biomarkers, DNA damage and repair, Epidemiology, Longevity, Life Style, Age Factors, Humans, Middle Aged, Risk Factors, Longevity/physiology, Male, Alcohol Drinking, Socioeconomic Factors, Telomere Shortening/physiology, Adult, Female, Aged, Leukocytes/pathology, Health Status, Longitudinal Studies, Smoking",

author = "Laila Bendix and Mikael Thinggaard and Mogens Fenger and Steen K{\o}lvraa and Kirsten Avlund and Linneberg, {Allan Ren{\'e}} and Merete Osler",

year = "2014",

month = feb,

doi = "10.1093/gerona/glt153",

language = "English",

volume = "69 A",

pages = "231--239",

journal = "Journals of Gerontology. Series A: Biological Sciences & Medical Sciences",

issn = "1079-5006",

publisher = "Heinemann",

number = "2",

}

TY - JOUR

T1 - Longitudinal Changes in Leukocyte Telomere Length and Mortality in Humans

AU - Bendix, Laila

AU - Thinggaard, Mikael

AU - Fenger, Mogens

AU - Kølvraa, Steen

AU - Avlund, Kirsten

AU - Linneberg, Allan René

AU - Osler, Merete

PY - 2014/2

Y1 - 2014/2

N2 - Leukocyte telomere length (LTL) ostensibly shortens with age and has been moderately associated with mortality. In humans, these findings have come almost solely from cross-sectional studies. Only recently has LTL shortening within individuals been analyzed in longitudinal studies. Such studies are relevant to establish LTL dynamics as biomarkers of mortality as well as to disentangle the causality of telomeres on aging.

AB - Leukocyte telomere length (LTL) ostensibly shortens with age and has been moderately associated with mortality. In humans, these findings have come almost solely from cross-sectional studies. Only recently has LTL shortening within individuals been analyzed in longitudinal studies. Such studies are relevant to establish LTL dynamics as biomarkers of mortality as well as to disentangle the causality of telomeres on aging.

KW - Biomarkers

KW - Longevity

KW - DNA damage and repair

KW - Epidemiology

KW - Biomarkers

KW - DNA damage and repair

KW - Epidemiology

KW - Longevity

KW - Life Style

KW - Age Factors

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Longevity/physiology

KW - Male

KW - Alcohol Drinking

KW - Socioeconomic Factors

KW - Telomere Shortening/physiology

KW - Adult

KW - Female

KW - Aged

KW - Leukocytes/pathology

KW - Health Status

KW - Longitudinal Studies

KW - Smoking

U2 - 10.1093/gerona/glt153

DO - 10.1093/gerona/glt153

M3 - Journal article

C2 - 24149432

VL - 69 A

SP - 231

EP - 239

JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

SN - 1079-5006

IS - 2

ER -

Longitudinal Changes in Leukocyte Telomere Length and Mortality in Humans

Abstract

Keywords

Documents & Links

Fingerprint

Cite this