Long-term Risk of Cancer Following Ileal Pouch-anal Anastomosis for Ulcerative Colitis

Anders Mark-Christensen, Rune Erichsen, Søren Brandsborg, Jacob Rosenberg, Niels Qvist, Ole Thorlacius-Ussing, Jens Hillingsø, Jørn Helmut Pachler, Erica Gould Christiansen, Søren Laurberg

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Background: The overall risk of cancer following ileal pouch-anal anastomosis [IPAA] is unknown, and pouch cancer surveillance is controversial. We evaluated long-term risk of cancer in a national cohort of patients with ulcerative colitis and IPAA, with emphasis on pouch cancer.

    Methods: Data on incident cancers were extracted from the national Danish Cancer Registry. Incidence rates for all site-specific cancers were compared between patients with IPAA and a gender- and age-matched comparison cohort from the background population to obtain incidence rate ratios [IRRs].

    Results: A total of 1723 patients with IPAA, operated for ulcerative colitis in the period 1980-2010, were matched to 8615 individuals from the background population. During a median follow-up of 12.9 years (interquartile range [IQR] 7.7-19.6 years), two pouch cancers [0.12%] were found after 16 and 27 years, respectively. In the population comparison cohort, 38 intestinal cancers [0.45%] were found, of which 35 were colorectal. The risk of hepatobiliary cancer was higher for patients with IPAA {IRR = 13.0 (95% confidence interval [CI]: 3.1-76.1)}, and half of the affected patients had coexisting primary sclerosing cholangitis. The risk of cancer overall following IPAA was identical to that of the comparison cohort: IRR = 1.05 [0.84-1.31].

    Conclusions: Pouch cancer following IPAA is very rare, questioning the need for general, rather than selective, surveillance. The overall cancer risk is comparable to that of the background population, and the increased risk of hepatobiliary cancer is likely an effect of coexisting liver disease and not causally related to IPAA.

    Original languageEnglish
    JournalJournal of Crohn's and Colitis
    Volume12
    Issue number1
    Pages (from-to)57–62
    ISSN1873-9946
    DOIs
    Publication statusPublished - 5. Jan 2018

    Keywords

    • Journal Article
    • Cancer
    • Ileal pouch-anal anastomosis
    • Ulcerative colitis
    • Colorectal Neoplasms/epidemiology
    • Follow-Up Studies
    • Biliary Tract Neoplasms/epidemiology
    • Humans
    • Liver Neoplasms/epidemiology
    • Colonic Pouches/pathology
    • Male
    • Case-Control Studies
    • Incidence
    • Young Adult
    • Denmark/epidemiology
    • Time Factors
    • Adult
    • Female
    • Registries
    • Cholangitis, Sclerosing/complications
    • Proctocolectomy, Restorative
    • Colitis, Ulcerative/complications

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