Long-term effectiveness of highly active antiretroviral therapy (HAART) in perinatally HIV-infected children in Denmark

Linda Bracher, Niels Henrik Valerius, Vibeke Rosenfeldt, Troels Herlin, Niels Fisker, Henrik Nielsen, Niels Obel

Research output: Contribution to journalJournal articleResearchpeer-review


The long-term impact of highly active antiretroviral therapy (HAART) on HIV-1 infected children is not well known. The Danish Paediatric HIV Cohort Study includes all patients <16 y of age with HIV-1 infection in Denmark. We report the complete follow-up from 1996 to 2005 of 49 perinatally infected children treated with HAART. Initial HAART included 2 nucleoside reverse-transcriptase inhibitors in combination with either a protease inhibitor (n =38) or a non-nucleoside reverse-transcriptase inhibitor (n =12). 19 (39%) patients were previously treated with mono- or dual therapy. Baseline characteristics were median CD4 percentage 14% and HIV-RNA viral load 4.9 log(10). Within the first 12 weeks of therapy approximately 60% achieved HIV-RNA viral load <500 copies/ml, and this remained stable for up to 8 y, although many children changed the components of HAART. The proportion of children with CD4 percentage >25% increased to 60-70% over the y of treatment. For the total cohort, 245 patient-y of observation were available with only 1 death. During our observation period there were no signs of a waning impact. The challenge remains to maintain a high adherence to therapy as the children grow into adolescence and develop more independence from family and health care staff.
Original languageEnglish
JournalScandinavian Journal of Infectious Diseases
Issue number9
Pages (from-to)799-804
Number of pages5
Publication statusPublished - 2007


  • Acquired Immunodeficiency Syndrome
  • Adolescent
  • Antiretroviral Therapy, Highly Active
  • Child
  • Child, Preschool
  • Cohort Studies
  • Denmark
  • Disease Transmission, Vertical
  • Female
  • HIV Protease Inhibitors
  • HIV-1
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Pregnancy
  • Pregnancy Complications, Infectious
  • Reverse Transcriptase Inhibitors


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