Long-acting inhalation treatment and the risk of urinary tract infection textendash a symmetry analysis

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Abstract

Background: Long-acting muscarinic antagonists (LAMA) have previously been associated with increased risk of urinary tract infections (UTI), but the association is not well-established. Further, it has not been proven whether long-acting inhalation treatment (LAIT [long-acting bronchodilators] and inhaled corticosteroids [ICS]) show the same association. The study aimed to assess the association between LAIT and UTI treatment.Methods A prescription sequence symmetry analysis was employed on all Danish residents aged >=18 years from 2000-2016, who filled their first ever prescription for LAIT and a prescription of antibiotics targeting UTI within an interval of 30 days before or after the LAIT initiation. We calculated the sequence ratio (SR) and corresponding 95% confidence intervals. The SR is the ratio between subjects with LAIT prescribed before UTI treatment and subjects with LAIT prescribed after, which is a valid estimate of the incidence rate ratio. The attributable number of post-LAIT UTI treatment was also calculated.Results: A total of 36,048 persons were identified initiating their first LAIT and UTI treatment within a 30-day days. Of those, 26,017 (72 were females; 1,948 initiated LAIT before and 1,663 initiated LAIT after UTI treatment (SR 1.17, 1.10-1.25). The attributable number was 285 (14.6. Male- and female SR was 1.30 (95%CI 1.16-1.48) and 1.12 (1.04-1.21), respectively. Patients with a CCI>=3 had the strongest association (SR 1.35, 1.15-1.61). The SR initiating LAMA, LABA, and ICS was 1.02 (0.83-1.28), 1.24 (0.99-1.58), and 1.19 (1.07-1.31) respectively.Conclusions: We found a weak association between the initiation of UTI treatment for ICS but not for LABA or LAMA.FootnotesCite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA2270.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
Original languageUndefined/Unknown
Article numberPA2270
JournalEuropean Respiratory Journal
Volume52
Issue numberSuppl. 62
Number of pages1
ISSN0903-1936
DOIs
Publication statusPublished - 2018
EventERS International Congress 2018 - Paris, France
Duration: 15. Sep 201819. Sep 2018

Conference

ConferenceERS International Congress 2018
CountryFrance
CityParis
Period15/09/201819/09/2018

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