Localization of surfactant protein-D in the rheumatoid synovial membrane

Anne Friesgaard Christensen, Grith Lykke Sorensen, Kirsten Junker, Peter Hvidbak Revald, Claus Varnum, Flemming Brandt Sorensen, Peter Junker

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Surfactant protein-D (SP-D) is a collectin, which plays an important role in airway protection and inflammation. The molecule has both pro- and anti-inflammatory capacities depending on its molecular size. Its involvement in joint diseases is largely unknown and the aim of this investigation was to study SP-D occurrence and distribution in the synovial membrane of patients with long-standing rheumatoid arthritis (RA) and osteoarthritis (OA). Six RA patients and six OA patients, who underwent total hip arthroplasty, were included in the study. Synovial tissue biopsies were obtained during surgery and subsequently prepared for immunohistochemistry. In this first, small-scale comparative study on the occurrence of SP-D in the synovial membrane of RA and OA, we report that SP-D was only present in the microvascular endothelium in subsynovial and pannus tissue and that the immunostaining was much stronger than in OA. This distribution pattern suggests that SP-D modulates RA inflammatory activities.

Original languageEnglish
JournalAPMIS
Volume126
Issue number1
Pages (from-to)9–13
ISSN0903-4641
DOIs
Publication statusPublished - 2018

Keywords

  • Journal Article
  • Rheumatoid arthritis
  • surfactant protein-D
  • synovial membrane
  • Humans
  • Middle Aged
  • Synovial Membrane/chemistry
  • Male
  • Osteoarthritis/metabolism
  • Female
  • Aged
  • Arthritis, Rheumatoid/metabolism
  • Pulmonary Surfactant-Associated Protein D/analysis

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