LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Sanjay K. Singh; Poul Nielsen; Alexei A. Koshkin; Jesper Wengel

doi:10.1039/A708608C

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Sanjay K. Singh
, Poul Nielsen
, Alexei A. Koshkin
, Jesper Wengel

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson–Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.

Original language	English
Journal	Chemical Communications
Volume	1998
Issue number	4
Pages (from-to)	455-456
ISSN	1359-7345
DOIs	https://doi.org/10.1039/A708608C
Publication status	Published - 1998

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@article{1320ff20e3a911dca57f000ea68e967b,

title = "LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition",

abstract = "A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson{\textendash}Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities. ",

author = "Singh, \{Sanjay K.\} and Poul Nielsen and Koshkin, \{Alexei A.\} and Jesper Wengel",

year = "1998",

doi = "10.1039/A708608C",

language = "English",

volume = "1998",

pages = "455--456",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "4",

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TY - JOUR

T1 - LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

AU - Singh, Sanjay K.

AU - Nielsen, Poul

AU - Koshkin, Alexei A.

AU - Wengel, Jesper

PY - 1998

Y1 - 1998

N2 - A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson–Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.

AB - A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson–Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.

U2 - 10.1039/A708608C

DO - 10.1039/A708608C

M3 - Journal article

SN - 1359-7345

VL - 1998

SP - 455

EP - 456

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Abstract

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