Lipid-lowering treatment to the end?

A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds

Line Kirkeby Petersen, Kaare Christensen, Jakob Kragstrup

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

People aged 80 or older are the fastest growing population in high-income countries. One of the most common causes of death among the elderly is the cardiovascular disease (CVD). Lipid-lowering treatment is common, e.g. one-third of 75-84-year-old Swedes are treated with statins. The assumption that hypercholesterolaemia is a risk factor at the highest ages seems to be based on extrapolation from younger adults. A review of observational studies shows a trend where all-cause mortality was highest when total cholesterol (TC) was lowest ('a reverse J-shaped' association between TC and all-cause mortality). Low TC (
Original languageEnglish
JournalAge and Ageing
Volume39
Issue number6
Pages (from-to)674-80
Number of pages7
ISSN0002-0729
DOIs
Publication statusPublished - 1. Nov 2010

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Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia
Young Adult
Cause of Death

Cite this

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title = "Lipid-lowering treatment to the end?: A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds",
abstract = "People aged 80 or older are the fastest growing population in high-income countries. One of the most common causes of death among the elderly is the cardiovascular disease (CVD). Lipid-lowering treatment is common, e.g. one-third of 75-84-year-old Swedes are treated with statins. The assumption that hypercholesterolaemia is a risk factor at the highest ages seems to be based on extrapolation from younger adults. A review of observational studies shows a trend where all-cause mortality was highest when total cholesterol (TC) was lowest ('a reverse J-shaped' association between TC and all-cause mortality). Low TC (",
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Lipid-lowering treatment to the end? A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds. / Petersen, Line Kirkeby; Christensen, Kaare; Kragstrup, Jakob.

In: Age and Ageing, Vol. 39, No. 6, 01.11.2010, p. 674-80.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Lipid-lowering treatment to the end?

T2 - A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds

AU - Petersen, Line Kirkeby

AU - Christensen, Kaare

AU - Kragstrup, Jakob

PY - 2010/11/1

Y1 - 2010/11/1

N2 - People aged 80 or older are the fastest growing population in high-income countries. One of the most common causes of death among the elderly is the cardiovascular disease (CVD). Lipid-lowering treatment is common, e.g. one-third of 75-84-year-old Swedes are treated with statins. The assumption that hypercholesterolaemia is a risk factor at the highest ages seems to be based on extrapolation from younger adults. A review of observational studies shows a trend where all-cause mortality was highest when total cholesterol (TC) was lowest ('a reverse J-shaped' association between TC and all-cause mortality). Low TC (

AB - People aged 80 or older are the fastest growing population in high-income countries. One of the most common causes of death among the elderly is the cardiovascular disease (CVD). Lipid-lowering treatment is common, e.g. one-third of 75-84-year-old Swedes are treated with statins. The assumption that hypercholesterolaemia is a risk factor at the highest ages seems to be based on extrapolation from younger adults. A review of observational studies shows a trend where all-cause mortality was highest when total cholesterol (TC) was lowest ('a reverse J-shaped' association between TC and all-cause mortality). Low TC (

U2 - 10.1093/ageing/afq129

DO - 10.1093/ageing/afq129

M3 - Journal article

VL - 39

SP - 674

EP - 680

JO - Age and Ageing

JF - Age and Ageing

SN - 0002-0729

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